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Review
. 2018 Feb;33(2):199-213.
doi: 10.1007/s00467-017-3599-2. Epub 2017 Feb 23.

Cell therapeutic approaches to immunosuppression after clinical kidney transplantation

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Review

Cell therapeutic approaches to immunosuppression after clinical kidney transplantation

Christian Morath et al. Pediatr Nephrol. 2018 Feb.

Abstract

Refinement of immunosuppressive strategies has led to further improvement of kidney graft survival in recent years. Currently, the main limitations to long-term graft survival are life-threatening side effects of immunosuppression and chronic allograft injury, emphasizing the need for innovative immunosuppressive regimens that resolve this therapeutic dilemma. Several cell therapeutic approaches to immunosuppression and donor-specific unresponsiveness have been tested in early phase I and phase II clinical trials in kidney transplantation. The aim of this overview is to summarize current cell therapeutic approaches to immunosuppression in clinical kidney transplantation with a focus on myeloid suppressor cell therapy by mitomycin C-induced cells (MICs). MICs show great promise as a therapeutic agent to achieve the rapid and durable establishment of donor-unresponsiveness in living-donor kidney transplantation. Cell-based therapeutic approaches may eventually revolutionize immunosuppression in kidney transplantation in the near future.

Keywords: Immunosuppression; Mitomycin C-induced cells; Myeloid suppressor cells; Regulatory T cells; Tolerance; Transplantation.

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