Effect of dezocine combined with propofol on painless gastroscopy in patients with suspect gastric carcinoma

Abstract

Objective: To evaluate the effect of dezocine combined with propofol on painless gastroscopy in patients with suspect gastric carcinoma.

Methods: Forty-three patients with gastric carcinoma who have underwent painless gastroscopy were retrospectively analyzed. For the 43 patients, 21 patients received propofol 1 mg/kg for painless gastroscopy (control group) and other 22 cases received dezocine 20 µg/kg plus propofol 1 mg/kg for painless gastroscopy (experiment group). The vital indexes (heart rate [HR], respiratory rate [RR], mean arterial pressure [MAP], and SpO2%), side effects, and recovery time were recorded at the time point T1 (before dosing), T2 (disappearance of eyelash reflex), and T3 (recovery of orientation).

Results: The HR, RR, and MAP were significantly decreased in T2 compared to T1 in both experiment and control group (P < 0.05). However, the SpO2% was not changed at T1, T2, and T3 in both experiment and control groups (P > 0.05). The RR at T2 was 16.8 ± 2.1 (n/ min) and 14.2 ± 1.8 (n/min) for experiment and control groups, respectively, with statistical difference (P < 0.05). The incidence rate of respiratory depression and body movement was 0.0%, 27.3% for experiment and 23.8%, 47.6% for control group with statistical difference (P < 0.05). The recovery time was 3.6 ± 0.8 min and 1.8 ± 0.6 min for control and experiment group, respectively, which demonstrated experiment group is much shorter than that of control group with statistical difference (P < 0.05). However, nausea and vomiting rate was not statistically different between the experiment and control groups (P > 0.05).

Conclusion: Dezocine combined with propofol on painless gastroscopy can reduce the respiratory depression and body movement without interference of hemodynamics.