Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar 1;8(1):37-43.
doi: 10.1515/bmc-2016-0029.

Alzheimer's disease as an inflammatory disease

Marta Bolós  1   2 , Juan Ramón Perea  1   2 , Jesús Avila  1   2
Affiliations
Free article
Review

Alzheimer's disease as an inflammatory disease

Marta Bolós et al. Biomol Concepts. .
Free article

Abstract

Alzheimer's disease (AD) is a neurodegenerative condition characterized by the formation of amyloid-β plaques, aggregated and hyperphosphorylated tau protein, activated microglia and neuronal cell death, ultimately leading to progressive dementia. In this short review, we focus on neuroinflammation in AD. Specifically, we describe the participation of microglia, as well as other factors that may contribute to inflammation, in neurodegeneration.

PubMed Disclaimer

References

    1. Alzheimer A. Über eine eigenartige Erkankung der Hirnrinde. Psych genchtl Med 1907; 64: 146–8.
    1. Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM. Alzheimer’s disease. Lancet 2016; 388: 505–17.
    1. Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer’s disease. Science 1987; 235: 877–80.
    1. Tanzi RE. The genetics of Alzheimer disease. Cold Spring Harb Perspect Med 2012; 2. pii: a006296. doi: 10.1101/cshperspect.a006296.
    1. McGeer PL, McGeer EG. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathol 2013; 126: 479–97.

MeSH terms

LinkOut - more resources