Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct 1;196(7):928-931.
doi: 10.1164/rccm.201608-1611LE.

Effects of Retinoids on Augmentation of Club Cell Secretory Protein

Yin Chen  1 , Monica M Vasquez  1 , Lingxiang Zhu  1 , Rosa E Lizarraga  1 , Mary Krutzsch  2 , Janine Einspahr  1   2 , David S Alberts  1   2 , Peter Y P Di  3 , Fernando D Martinez  1 , Stefano Guerra  1   4
Affiliations

Effects of Retinoids on Augmentation of Club Cell Secretory Protein

Yin Chen et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Serum club cell secretory protein (CC16) levels at baseline, during, and after treatment in 71 subjects who participated in a placebo-controlled vitamin A trial for severely sun-damaged skin (11). CC16 levels (geometric mean ± SE) are shown for the placebo and the three treatment groups (vitamin A [retinyl palmitate] at 25,000, 50,000, or 75,000 IU/d) at baseline and at 3, 6, and 12 months of treatment. Number of subjects: Placebo (n = 20), 25,000 IU/d (n = 18), 50,000 IU/d (n = 15), and 75,000 IU/d (n = 18). P values (shown above error bars) refer to comparison with placebo group at each time point. Data were analyzed using random coefficients models to take into account intrasubject serial correlation. All analyses were adjusted for sex, age, and smoking status. *CC16 levels at 12 months significantly higher than baseline CC16 levels for treatment groups receiving 50,000 and 75,000 IU/d. NS = not significant.
Figure 2.
Figure 2.
Dose-dependent club cell secretory protein (CC16) production in primary human bronchial epithelial cell cultures from normal individuals with no respiratory diseases (left) and from patients with COPD (GOLD stage IV; right) under immersed conditions in response to various doses of t-RA or RAR-specific agonist treatment. RAR-specific agonists included AM580 for RARα, CD2314 for RARβ, and CD1530 for RARγ. Secreted CC16 was measured in the culture medium. Values represent means ± SEM 72 hours after treatment. Number of subjects: Normal (n = 9), patients with COPD (n = 4). *P < 0.01 compared with untreated. COPD = chronic obstructive pulmonary disease; GOLD = Global Initiative for Chronic Obstructive Lung Disease; RAR = retinoic acid receptor; t-RA = all-trans-retinoic acid.
See this image and copyright information in PMC

References

    1. Singh G, Katyal SK. Secretory proteins of Clara cells and type II cells. In: Parent RA, editor. Comparative biology of the normal lung. Boca Raton, FL: CRC Press; 1992. pp. 93–108.
    1. Laucho-Contreras ME, Polverino F, Gupta K, Taylor KL, Kelly E, Pinto-Plata V, Divo M, Ashfaq N, Petersen H, Stripp B, et al. Protective role for club cell secretory protein-16 (CC16) in the development of COPD. Eur Respir J. 2015;45:1544–1556. - PMC - PubMed
    1. Guerra S, Halonen M, Vasquez MM, Spangenberg A, Stern DA, Morgan WJ, Wright AL, Lavi I, Tarès L, Carsin AE, et al. Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study. Lancet Respir Med. 2015;3:613–620. - PMC - PubMed
    1. Gamez AS, Gras D, Petit A, Knabe L, Molinari N, Vachier I, Chanez P, Bourdin A. Supplementing defect in club cell secretory protein attenuates airway inflammation in COPD. Chest. 2015;147:1467–1476. - PubMed
    1. Shi W, Chen F, Cardoso WV. Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009;6:558–563. - PMC - PubMed

Publication types

MeSH terms