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. 2017 Oct 1;196(7):928-931.
doi: 10.1164/rccm.201608-1611LE.

Effects of Retinoids on Augmentation of Club Cell Secretory Protein

Yin Chen  1 , Monica M Vasquez  1 , Lingxiang Zhu  1 , Rosa E Lizarraga  1 , Mary Krutzsch  2 , Janine Einspahr  1   2 , David S Alberts  1   2 , Peter Y P Di  3 , Fernando D Martinez  1 , Stefano Guerra  1   4
Affiliations

Effects of Retinoids on Augmentation of Club Cell Secretory Protein

Yin Chen et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Serum club cell secretory protein (CC16) levels at baseline, during, and after treatment in 71 subjects who participated in a placebo-controlled vitamin A trial for severely sun-damaged skin (11). CC16 levels (geometric mean ± SE) are shown for the placebo and the three treatment groups (vitamin A [retinyl palmitate] at 25,000, 50,000, or 75,000 IU/d) at baseline and at 3, 6, and 12 months of treatment. Number of subjects: Placebo (n = 20), 25,000 IU/d (n = 18), 50,000 IU/d (n = 15), and 75,000 IU/d (n = 18). P values (shown above error bars) refer to comparison with placebo group at each time point. Data were analyzed using random coefficients models to take into account intrasubject serial correlation. All analyses were adjusted for sex, age, and smoking status. *CC16 levels at 12 months significantly higher than baseline CC16 levels for treatment groups receiving 50,000 and 75,000 IU/d. NS = not significant.
Figure 2.
Figure 2.
Dose-dependent club cell secretory protein (CC16) production in primary human bronchial epithelial cell cultures from normal individuals with no respiratory diseases (left) and from patients with COPD (GOLD stage IV; right) under immersed conditions in response to various doses of t-RA or RAR-specific agonist treatment. RAR-specific agonists included AM580 for RARα, CD2314 for RARβ, and CD1530 for RARγ. Secreted CC16 was measured in the culture medium. Values represent means ± SEM 72 hours after treatment. Number of subjects: Normal (n = 9), patients with COPD (n = 4). *P < 0.01 compared with untreated. COPD = chronic obstructive pulmonary disease; GOLD = Global Initiative for Chronic Obstructive Lung Disease; RAR = retinoic acid receptor; t-RA = all-trans-retinoic acid.
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