Finding the Optimal Tradeoffs

Shibin Mathew¹, Amy E Thurber², Suzanne Gaudet³

Affiliations

¹ Department of Cancer Biology and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
² Department of Cancer Biology and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.
³ Department of Cancer Biology and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: suzanne_gaudet@dfci.harvard.edu.

PMID: 28231448
DOI: 10.1016/j.cels.2017.02.002

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Finding the Optimal Tradeoffs

Shibin Mathew et al. Cell Syst. 2017.

Free article

. 2017 Feb 22;4(2):149-151.

doi: 10.1016/j.cels.2017.02.002.

Authors

Shibin Mathew¹, Amy E Thurber², Suzanne Gaudet³

Affiliations

¹ Department of Cancer Biology and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
² Department of Cancer Biology and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.
³ Department of Cancer Biology and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: suzanne_gaudet@dfci.harvard.edu.

PMID: 28231448
DOI: 10.1016/j.cels.2017.02.002

Abstract

Computational analyses of a half-million circuit topologies provide a rationale for why certain fold-change detection topologies are more prevalent in nature.

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Optimal Regulatory Circuit Topologies for Fold-Change Detection.
Adler M, Szekely P, Mayo A, Alon U. Adler M, et al. Cell Syst. 2017 Feb 22;4(2):171-181.e8. doi: 10.1016/j.cels.2016.12.009. Epub 2017 Jan 11. Cell Syst. 2017. PMID: 28089543

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Finding the Optimal Tradeoffs

Affiliations

Finding the Optimal Tradeoffs

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