Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul:175:133-150.
doi: 10.1016/j.pharmthera.2017.02.041. Epub 2017 Feb 22.

Cannabidiol: State of the art and new challenges for therapeutic applications

Simona Pisanti  1 , Anna Maria Malfitano  2 , Elena Ciaglia  2 , Anna Lamberti  2 , Roberta Ranieri  2 , Gaia Cuomo  2 , Mario Abate  2 , Giorgio Faggiana  2 , Maria Chiara Proto  3 , Donatella Fiore  3 , Chiara Laezza  4 , Maurizio Bifulco  5
Affiliations
Review

Cannabidiol: State of the art and new challenges for therapeutic applications

Simona Pisanti et al. Pharmacol Ther. 2017 Jul.

Abstract

Over the past years, several lines of evidence support a therapeutic potential of Cannabis derivatives and in particular phytocannabinoids. Δ9-THC and cannabidiol (CBD) are the most abundant phytocannabinoids in Cannabis plants and therapeutic application for both compounds have been suggested. However, CBD is recently emerging as a therapeutic agent in numerous pathological conditions since devoid of the psychoactive side effects exhibited instead by Δ9-THC. In this review, we highlight the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function. Furthermore, the therapeutic potential of cannabidiol is also highlighted, in particular in nuerological diseases and cancer.

Keywords: Cancer; Cannabidiol; Cannabis; Endocannabinoid system; Neurological diseases.

PubMed Disclaimer