Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1987 Nov;84(21):7478-82.
doi: 10.1073/pnas.84.21.7478.

Identification of a vaccinia virus gene encoding a type I DNA topoisomerase

S Shuman  1 , B Moss
Affiliations
Comparative Study

Identification of a vaccinia virus gene encoding a type I DNA topoisomerase

S Shuman et al. Proc Natl Acad Sci U S A. 1987 Nov.

Abstract

Vaccinia virus encapsidates a type I DNA topoisomerase (EC 5.99.1.2). The enzyme was purified from virus cores to apparent homogeneity, yielding a protein of Mr 32,000. The amino-terminal sequence of the isolated Mr 32,000 polypeptide was determined and used to map the putative structural gene for the vaccinia topoisomerase to the H7r open reading frame of the vaccinia genome. This gene encodes a 314-amino acid polypeptide containing a region homologous to a region of the type I topoisomerase from the yeast Saccharomyces cerevisiae.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 1974 May 25;249(10):3292-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Sep;84(18):6417-21 - PubMed
    1. J Biol Chem. 1978 Jan 25;253(2):511-8 - PubMed
    1. J Biol Chem. 1981 May 25;256(10):4805-9 - PubMed
    1. J Virol. 1984 Jan;49(1):1-8 - PubMed

Publication types

MeSH terms

Substances