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. 2017 May;21(2):463-473.
doi: 10.1007/s11030-017-9730-2. Epub 2017 Feb 23.

A general three-step one-pot synthesis of novel (E)-6-chloro-2-(aryl/hetarylvinyl)quinoline-3-carboxylic acids

Yang Li  1   2 , Yang Wang  3 , Hongtao Zou  4
Affiliations

A general three-step one-pot synthesis of novel (E)-6-chloro-2-(aryl/hetarylvinyl)quinoline-3-carboxylic acids

Yang Li et al. Mol Divers. 2017 May.

Abstract

In this work, a facile and general three-step one-pot synthesis of structurally new (E)-6-chloro-2-(aryl/hetarylvinyl)quinoline-3-carboxylic acid derivatives has been achieved from easily available ethyl 6-chloro-2-(chloromethyl) quinoline-3-carboxylate and aromatic or heteroaromatic aldehydes. This strategy features simple one-pot operation, tolerance of a wide range of substituents, and good yields. Moreover, these newly synthesized compounds belong to a new class of quinoline derivatives and could be good candidates for the development of more complex quinoline compounds for use in medicinal chemistry.

Keywords: Aromatic aldehydes; Carboxylic acid; Quinoline; Three-step one-pot.

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