Less is more: the role of mTORC1 activation in the progression of ageing-mediated anabolic resistance

doi:10.1113/JP274154

Comment

. 2017 May 1;595(9):2781-2782.

doi: 10.1113/JP274154.

Less is more: the role of mTORC1 activation in the progression of ageing-mediated anabolic resistance

Cory M Dungan¹

Affiliations

PMID: 28233314
PMCID: PMC5407973
DOI: 10.1113/JP274154

Comment

Less is more: the role of mTORC1 activation in the progression of ageing-mediated anabolic resistance

Cory M Dungan. J Physiol. 2017.

. 2017 May 1;595(9):2781-2782.

doi: 10.1113/JP274154.

Author

Cory M Dungan¹

Affiliation

¹ Center for Muscle Biology and Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, KY, 40536, USA.

PMID: 28233314
PMCID: PMC5407973
DOI: 10.1113/JP274154

No abstract available

Keywords: Ageing; anabolic resistance; mtor.

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Comment on

Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age-related anabolic resistance to exercise in humans.
Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Phillips BE, Szewczyk NJ, Greenhaff PL, Smith K, Atherton PJ. Brook MS, et al. J Physiol. 2016 Dec 15;594(24):7399-7417. doi: 10.1113/JP272857. Epub 2016 Nov 7. J Physiol. 2016. PMID: 27654940 Free PMC article. Clinical Trial.

References

1. Bentzinger CF, Lin S, Romanino K, Castets P, Guridi M, Summermatter S, Handschin C, Tintignac LA, Hall MN & Rüegg MA (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skelet Muscle 3, 6. - PMC - PubMed
1. Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Phillips BE, Szewczyk NJ, Greenhaff PL, Smith K & Atherton PJ (2016). Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans. J Physiol 594, 7399–7417. - PMC - PubMed
1. Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M & Rüegg MA (2013). Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation‐induced autophagy and causes a severe, late‐onset myopathy. Cell Metab 17, 731–744. - PubMed
1. Kirby TJ, Lee JD, England JH, Chaillou T, Esser KA & McCarthy JJ (2015). Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis. J Appl Physiol (1985) 119, 321–327. - PMC - PubMed
1. Markofski MM, Dickinson JM, Drummond MJ, Fry CS, Fujita S, Gundermann DM, Glynn EL, Jennings K, Paddon‐Jones D, Reidy PT, Sheffield‐Moore M, Timmerman KL, Rasmussen BB & Volpi E (2015). Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women. Exp Gerontol 65, 1–7. - PMC - PubMed

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[1] Bentzinger CF, Lin S, Romanino K, Castets P, Guridi M, Summermatter S, Handschin C, Tintignac LA, Hall MN & Rüegg MA (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skelet Muscle 3, 6. - PMC - PubMed

[2] Bentzinger CF, Lin S, Romanino K, Castets P, Guridi M, Summermatter S, Handschin C, Tintignac LA, Hall MN & Rüegg MA (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skelet Muscle 3, 6. - PMC - PubMed

[3] Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Phillips BE, Szewczyk NJ, Greenhaff PL, Smith K & Atherton PJ (2016). Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans. J Physiol 594, 7399–7417. - PMC - PubMed

[4] Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Phillips BE, Szewczyk NJ, Greenhaff PL, Smith K & Atherton PJ (2016). Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans. J Physiol 594, 7399–7417. - PMC - PubMed

[5] Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M & Rüegg MA (2013). Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation‐induced autophagy and causes a severe, late‐onset myopathy. Cell Metab 17, 731–744. - PubMed

[6] Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M & Rüegg MA (2013). Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation‐induced autophagy and causes a severe, late‐onset myopathy. Cell Metab 17, 731–744. - PubMed

[7] Kirby TJ, Lee JD, England JH, Chaillou T, Esser KA & McCarthy JJ (2015). Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis. J Appl Physiol (1985) 119, 321–327. - PMC - PubMed

[8] Kirby TJ, Lee JD, England JH, Chaillou T, Esser KA & McCarthy JJ (2015). Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis. J Appl Physiol (1985) 119, 321–327. - PMC - PubMed

[9] Markofski MM, Dickinson JM, Drummond MJ, Fry CS, Fujita S, Gundermann DM, Glynn EL, Jennings K, Paddon‐Jones D, Reidy PT, Sheffield‐Moore M, Timmerman KL, Rasmussen BB & Volpi E (2015). Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women. Exp Gerontol 65, 1–7. - PMC - PubMed

[10] Markofski MM, Dickinson JM, Drummond MJ, Fry CS, Fujita S, Gundermann DM, Glynn EL, Jennings K, Paddon‐Jones D, Reidy PT, Sheffield‐Moore M, Timmerman KL, Rasmussen BB & Volpi E (2015). Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women. Exp Gerontol 65, 1–7. - PMC - PubMed

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Less is more: the role of mTORC1 activation in the progression of ageing-mediated anabolic resistance

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Less is more: the role of mTORC1 activation in the progression of ageing-mediated anabolic resistance

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