Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 May 1;595(9):2781-2782.
doi: 10.1113/JP274154.

Less is more: the role of mTORC1 activation in the progression of ageing-mediated anabolic resistance

Cory M Dungan  1
Affiliations
Comment

Less is more: the role of mTORC1 activation in the progression of ageing-mediated anabolic resistance

Cory M Dungan. J Physiol. .
No abstract available

Keywords: Ageing; anabolic resistance; mtor.

PubMed Disclaimer

Comment on

References

    1. Bentzinger CF, Lin S, Romanino K, Castets P, Guridi M, Summermatter S, Handschin C, Tintignac LA, Hall MN & Rüegg MA (2013). Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy. Skelet Muscle 3, 6. - PMC - PubMed
    1. Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Phillips BE, Szewczyk NJ, Greenhaff PL, Smith K & Atherton PJ (2016). Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans. J Physiol 594, 7399–7417. - PMC - PubMed
    1. Castets P, Lin S, Rion N, Di Fulvio S, Romanino K, Guridi M, Frank S, Tintignac LA, Sinnreich M & Rüegg MA (2013). Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation‐induced autophagy and causes a severe, late‐onset myopathy. Cell Metab 17, 731–744. - PubMed
    1. Kirby TJ, Lee JD, England JH, Chaillou T, Esser KA & McCarthy JJ (2015). Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis. J Appl Physiol (1985) 119, 321–327. - PMC - PubMed
    1. Markofski MM, Dickinson JM, Drummond MJ, Fry CS, Fujita S, Gundermann DM, Glynn EL, Jennings K, Paddon‐Jones D, Reidy PT, Sheffield‐Moore M, Timmerman KL, Rasmussen BB & Volpi E (2015). Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women. Exp Gerontol 65, 1–7. - PMC - PubMed

Substances

LinkOut - more resources