[Immunogenic properties of virus-specific soluble structural glycoproteins synthesized by chick embryo fibroblast cells infected with 2 strains of Aujeszky's disease virus]

Abstract

Studied was the capacity of the soluble virus-specific glycoproteins of the virulent A-2 strain and its IUDR-resistant MK-25 mutant to induce the production of virus-neutralizing antibodies. It was found that both the purified virions and soluble glycoproteins of strain A-2 and those of strain MK-25 induced the release of virus-neutralizing antibodies in the injected rabbits. Use was made of affinity chromatography on Con-A-Sepharose to isolate the glycosylated virus-specific proteins. The quality of the soluble virus-specific glycoproteins to trigger the production of virus-neutralizing antibodies made it reasonable to believe that the virus glycoproteins are structural ones.