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. 2017 Feb 23;168(5):749-750.
doi: 10.1016/j.cell.2017.02.013.

Doubling Down on Mutant RAS Can MEK or Break Leukemia

Zuzana Tothova  1 , Benjamin L Ebert  2
Affiliations
Free article

Doubling Down on Mutant RAS Can MEK or Break Leukemia

Zuzana Tothova et al. Cell. .
Free article

Abstract

Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive biomarker.

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  • KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
    Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K. Burgess MR, et al. Cell. 2017 Feb 23;168(5):817-829.e15. doi: 10.1016/j.cell.2017.01.020. Epub 2017 Feb 16. Cell. 2017. PMID: 28215705 Free PMC article.

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