Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Oct;43(10):1507-1509.
doi: 10.1007/s00134-017-4727-y. Epub 2017 Feb 24.

Intensive care medicine in 2050: precision medicine

Hector R Wong  1   2
Affiliations
Editorial

Intensive care medicine in 2050: precision medicine

Hector R Wong. Intensive Care Med. 2017 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

The Cincinnati Children’s Research Foundation and the author hold U.S. patents and have U.S. patents pending for some of the enrichment strategies described in this manuscript.

Figures

Figure
Figure. Schematic depicting a general approach to the application of prognostic and predictive enrichment strategies in critical illness
Individual patients in a sepsis cohort, as an example, are represented by circles, filled with different coloring to reflect patients with similar prognostic and predictive characteristics. See text for further details.
See this image and copyright information in PMC

References

    1. Dickmann LJ, Ware JA. Pharmacogenomics in the age of personalized medicine. Drug Discov Today Technol. 2016;21–22:11–16. - PubMed
    1. Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372:793–795. - PMC - PubMed
    1. Wong HR, Atkinson SJ, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Lindsell CJ. Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids. Crit Care Med. 2016;44:e1000–1003. - PMC - PubMed
    1. Langley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG, Jr, Rivers EP, Woods CW, Kingsmore SF. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med. 2013;5:195ra195. - PMC - PubMed
    1. Wong HR, Salisbury S, Xiao Q, Cvijanovich NZ, Hall M, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Sen A, Nowak J, Quasney M, Henricksen JW, Chopra A, Banschbach S, Beckman E, Harmon K, Lahni P, Lindsell CJ. The pediatric sepsis biomarker risk model. Crit Care. 2012;16:R174. - PMC - PubMed

Publication types

LinkOut - more resources