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. 2017 Sep-Oct;45(5):425-431.
doi: 10.1016/j.aller.2016.10.020. Epub 2017 Feb 21.

Immune response of toddlers with history of prematurity

S P Muraro  1 , P M Pitrez  2 , A P D de Souza  1 , B N Porto  1 , J E Vargas  1 , I P Ewald  1 , J P Heinzmann-Filho  3 , G Dos Santos  3 , T S Baptista  4 , T D Gandolfi  5 , F D Machado  5 , M H Jones  3 , C Bonorino  4 , R T Stein  6
Affiliations

Immune response of toddlers with history of prematurity

S P Muraro et al. Allergol Immunopathol (Madr). 2017 Sep-Oct.

Abstract

Background: It is not quite well established how immune responses differ in term and preterm infants beyond the first year of life. This study aimed to evaluate aspects of the innate and adaptive immune responses in a group of preterm infants in comparison with their term peers.

Methods: In this cross-sectional study peripheral blood mononuclear cells (PBMC) were isolated from preterm and term children at age three years. Innate immune response was evaluated by the analysis of TLR receptors expression on CD11c+HLADRhigh cells and inflammatory cytokine production after PBMC stimulation with Toll like receptors (TLR) ligands. Adaptive immune response was evaluated by T cells' phenotyping and function after stimulation with polyclonal conventional T cell stimulus.

Conclusion: We have found that the patterns of innate and adaptive immune responses at 3 years of age were not affected by the fact of the children having being born preterm or at term.

Keywords: Cytokines; Immune response; Memory T cell; Preterm children; TLR expression.

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