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Review
. 2017 Mar:22:38-43.
doi: 10.1016/j.prrv.2016.12.002. Epub 2016 Dec 14.

MicroRNAs in Lung Development and Disease

Dustin Ameis  1 , Naghmeh Khoshgoo  1 , Barbara M Iwasiow  1 , Phillip Snarr  1 , Richard Keijzer  2
Affiliations
Review

MicroRNAs in Lung Development and Disease

Dustin Ameis et al. Paediatr Respir Rev. 2017 Mar.

Abstract

MicroRNAs (miRNAs) are small (∼22 nucleotides), non-coding RNA molecules that regulate gene expression post-transcriptionally by inhibiting target mRNAs. Research into the roles of miRNAs in lung development and disease is at the early stages. In this review, we discuss the role of miRNAs in pediatric respiratory disease, including cystic fibrosis, asthma, and bronchopulmonary dysplasia.

Keywords: MicroRNAs; asthma; bronchopulmonary dysplasia; cystic fibrosis; gene expression; lung development.

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