Heritability of the femoral intima media thickness

Bence Fejer¹, Adam D Tarnoki², David L Tarnoki³, Pierleone Lucatelli⁴, Levente Littvay⁵, Pal Maurovich-Horvat⁶, Adam L Jermendy⁷, Attila Kovacs⁸, Erika Godor⁹, Corrado Fagnani¹⁰, Maria A Stazi¹¹, Andrea A Molnar¹², Fabrizio Fanelli¹³, Carlo Cirelli¹⁴, Filippo Farina¹⁵, Claudio Baracchini¹⁶, Giorgio Meneghetti¹⁷, Giacomo Pucci¹⁸, Gyorgy Jermendy¹⁹, Bela Merkely²⁰, Giuseppe Schillaci²¹, Emanuela Medda²²

Affiliations

¹ Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary. Electronic address: bence.fejer@gmail.com.
² Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary; Hungarian Twin Registry, 29 Erdélyi Street, Budapest 1212, Hungary. Electronic address: tarnoki2@gmail.com.
³ Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary; Hungarian Twin Registry, 29 Erdélyi Street, Budapest 1212, Hungary. Electronic address: tarnoki4@gmail.com.
⁴ Vascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. Electronic address: pierleone.lucatelli@gmail.com.
⁵ Central European University, 9 Nador Street, Budapest 1051, Hungary. Electronic address: levi@littvay.hu.
⁶ MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary. Electronic address: maurovich.horvat@gmail.com.
⁷ MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary. Electronic address: adam.jermendy@gmail.com.
⁸ MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary. Electronic address: kovatti@gmail.com.
⁹ Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary. Electronic address: godorerika@gmail.com.
¹⁰ Genetic Epidemiology Unit, National Centre of Epidemiology, Surveillance and Health Promotion; Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: corrado.fagnani@iss.it.
¹¹ Genetic Epidemiology Unit, National Centre of Epidemiology, Surveillance and Health Promotion; Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: stazi@iss.it.
¹² MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary; Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences, Semmelweis University, 44 Róbert Károly Krt., Budapest 1134, Hungary; Department of Cardiology, Military Hospital, 44 Róbert Károly Krt.., Budapest 1134, Hungary. Electronic address: molnandi@gmail.com.
¹³ Vascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. Electronic address: fabrizio.fanelli@uniroma1.it.
¹⁴ Vascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. Electronic address: dottcirelli@gmail.com.
¹⁵ Department of Neurosciences, University of Padua School of Medicine, via Giustiniani 5, 35128 Padova, Italy. Electronic address: farippo@gmail.com.
¹⁶ Department of Neurosciences, University of Padua School of Medicine, via Giustiniani 5, 35128 Padova, Italy. Electronic address: claudiobaracchini@gmail.com.
¹⁷ Department of Neurosciences, University of Padua School of Medicine, via Giustiniani 5, 35128 Padova, Italy. Electronic address: giorgio.meneghetti@unipd.it.
¹⁸ Università di Perugia, Unità di Medicina Interna, Ospedale "S. Maria", Viale Tristano di Joannuccio, 1, 05100 Terni, Italy. Electronic address: giacomo.pucci@gmail.com.
¹⁹ 3rd Department of Internal Medicine, Bajcsy Zsilinszky Hospital, 89-91 Maglódi Street, Budapest 1106, Hungary. Electronic address: gyjermendy@mail.datanet.hu.
²⁰ MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary. Electronic address: merkely.bela@gmail.com.
²¹ Università di Perugia, Unità di Medicina Interna, Ospedale "S. Maria", Viale Tristano di Joannuccio, 1, 05100 Terni, Italy. Electronic address: giuseppe.schillaci@unipg.it.
²² Genetic Epidemiology Unit, National Centre of Epidemiology, Surveillance and Health Promotion; Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: emanuela.medda@iss.it.

PMID: 28237540
DOI: 10.1016/j.ejim.2017.02.019

Multicenter Study

Heritability of the femoral intima media thickness

Bence Fejer et al. Eur J Intern Med. 2017 Jun.

. 2017 Jun:41:44-48.

doi: 10.1016/j.ejim.2017.02.019. Epub 2017 Feb 23.

Authors

Affiliations

¹ Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary. Electronic address: bence.fejer@gmail.com.
² Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary; Hungarian Twin Registry, 29 Erdélyi Street, Budapest 1212, Hungary. Electronic address: tarnoki2@gmail.com.
³ Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary; Hungarian Twin Registry, 29 Erdélyi Street, Budapest 1212, Hungary. Electronic address: tarnoki4@gmail.com.
⁴ Vascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. Electronic address: pierleone.lucatelli@gmail.com.
⁵ Central European University, 9 Nador Street, Budapest 1051, Hungary. Electronic address: levi@littvay.hu.
⁶ MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary. Electronic address: maurovich.horvat@gmail.com.
⁷ MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary. Electronic address: adam.jermendy@gmail.com.
⁸ MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary. Electronic address: kovatti@gmail.com.
⁹ Department of Radiology, Semmelweis University, 78/A Üllői Street, Budapest 1082, Hungary. Electronic address: godorerika@gmail.com.
¹⁰ Genetic Epidemiology Unit, National Centre of Epidemiology, Surveillance and Health Promotion; Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: corrado.fagnani@iss.it.
¹¹ Genetic Epidemiology Unit, National Centre of Epidemiology, Surveillance and Health Promotion; Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: stazi@iss.it.
¹² MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary; Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences, Semmelweis University, 44 Róbert Károly Krt., Budapest 1134, Hungary; Department of Cardiology, Military Hospital, 44 Róbert Károly Krt.., Budapest 1134, Hungary. Electronic address: molnandi@gmail.com.
¹³ Vascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. Electronic address: fabrizio.fanelli@uniroma1.it.
¹⁴ Vascular and Interventional Radiology Unit, Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy. Electronic address: dottcirelli@gmail.com.
¹⁵ Department of Neurosciences, University of Padua School of Medicine, via Giustiniani 5, 35128 Padova, Italy. Electronic address: farippo@gmail.com.
¹⁶ Department of Neurosciences, University of Padua School of Medicine, via Giustiniani 5, 35128 Padova, Italy. Electronic address: claudiobaracchini@gmail.com.
¹⁷ Department of Neurosciences, University of Padua School of Medicine, via Giustiniani 5, 35128 Padova, Italy. Electronic address: giorgio.meneghetti@unipd.it.
¹⁸ Università di Perugia, Unità di Medicina Interna, Ospedale "S. Maria", Viale Tristano di Joannuccio, 1, 05100 Terni, Italy. Electronic address: giacomo.pucci@gmail.com.
¹⁹ 3rd Department of Internal Medicine, Bajcsy Zsilinszky Hospital, 89-91 Maglódi Street, Budapest 1106, Hungary. Electronic address: gyjermendy@mail.datanet.hu.
²⁰ MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 18 Hataror Street, Budapest 1122, Hungary. Electronic address: merkely.bela@gmail.com.
²¹ Università di Perugia, Unità di Medicina Interna, Ospedale "S. Maria", Viale Tristano di Joannuccio, 1, 05100 Terni, Italy. Electronic address: giuseppe.schillaci@unipg.it.
²² Genetic Epidemiology Unit, National Centre of Epidemiology, Surveillance and Health Promotion; Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address: emanuela.medda@iss.it.

PMID: 28237540
DOI: 10.1016/j.ejim.2017.02.019

Abstract

Background: The measurement of femoral intima-media thickness (IMT) is underutilized in the clinical practice, although it is a surrogate marker of cardiovascular disease.

Materials and methods: 388 Hungarian and Italian twins (121 monozygotic, 73 dizygotic pairs) underwent bilateral B-mode sonography of femoral arteries. IMT was measured by semiautomated software, where available, or by calipers.

Results: Within-pair correlation in monozygotic twins was higher than in dizygotics for each parameter. Age-, sex- and country-adjusted genetic effect accounted for 43.9% (95% confidence interval, CI 21.3%-65.2%) and 47.2% (95% CI, 31.4%-62.6%) of the variance of common and superficial femoral artery IMT, respectively, and unshared environmental effect for 56.1% (95% CI 34.6%-78.5%) and 52.8% (95% CI, 37.2%-68.5%). These results did not change significantly after correcting for body mass index or central systolic blood pressure.

Conclusions: Genetic factors have a moderate role in the determination of common and superficial femoral IMT; however, the influence of environmental (lifestyle) factors remains still relevant. Environmental factors may have a role in influencing the genetic predisposition for femoral vascular hypertrophy.

Keywords: Atherosclerosis; Cardiovascular risk; Circulation; Gene; Twins.

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Heritability of the femoral intima media thickness

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Heritability of the femoral intima media thickness

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