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. 2017:1570:47-71.
doi: 10.1007/978-1-4939-6840-4_4.

Magnetic Characterization of Iron Oxide Nanoparticles for Biomedical Applications

Lorena Maldonado-Camargo  1 , Mythreyi Unni  1 , Carlos Rinaldi  2   3
Affiliations

Magnetic Characterization of Iron Oxide Nanoparticles for Biomedical Applications

Lorena Maldonado-Camargo et al. Methods Mol Biol. 2017.

Abstract

Iron oxide nanoparticles are of interest in a wide range of biomedical applications due to their response to applied magnetic fields and their unique magnetic properties. Magnetization measurements in constant and time-varying magnetic field are often carried out to quantify key properties of iron oxide nanoparticles. This chapter describes the importance of thorough magnetic characterization of iron oxide nanoparticles intended for use in biomedical applications. A basic introduction to relevant magnetic properties of iron oxide nanoparticles is given, followed by protocols and conditions used for measurement of magnetic properties, along with examples of data obtained from each measurement, and methods of data analysis.

Keywords: Anisotropy constant; Blocking temperature; Coercivity; Magnetic nanoparticles; Magnetic relaxation; Remanent magnetization; Saturation magnetization.

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Figures

Fig. 1
Fig. 1
Sample preparation. (a) 500 μL of the mixture iron oxide nanoparticles and poly(styrene-divinylbenzene) in glass test tubes. (b) Iron oxide nanoparticles immobilized in a poly(styrene-divinylbenzene). (c) Iron oxide nanoparticles in water solution
Fig. 2
Fig. 2
(a) Magnetization curves of iron oxide nanoparticles in a poly(styrene-divinylbenzene) matrix measured at different saturation fields. Annotations indicate the magnetic diameter and the geometric deviation calculated using the Langevin-Chantrel model. Inset figure shows the magnetic diameter distribution. (b) Magnetization curve at 300 K for iron oxide nanoparticles in a poly(styrene-divinylbenzene) matrix. Annotations indicate the magnetic diameter (14 nm) and the geometric deviation (ln σ = 0.246)
Fig. 3
Fig. 3
(a) Low field magnetization curves for iron oxide nanoparticles in a poly(styrene-divinylbenzene) matrix, at temperatures between 4 K and 400 K and (b) initial susceptibility data fitted to Curie-Weiss model
Fig. 4
Fig. 4
Zero field cooled (closed symbols) and field cooled (open symbols) magnetization curve for iron oxide nanoparticles in a poly(styrene-divinylbenzene) matrix, obtained at temperatures between 4 and 400 K using a 796 A/m (10 Oe) field
Fig. 5
Fig. 5
(a) In-phase component of the dynamic susceptibility with frequency for iron oxide nanoparticles in a poly(styrene-divinylbenzene) matrix. (b) Inverse applied field frequency as a function of the inverse temperature corresponding to the peak of in-phase component of dynamic susceptibility using the Néel and the Volger-Fuchler model
Fig. 6.
Fig. 6.
DMS spectra for liquid samples of (a) iron oxide and (b) cobalt ferrite nanoparticles in 1-octadecene at 298 K
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