Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Sep;22(5):89-92.

A Case of Amelanotic Malignant Melanoma of the Maxillary Sinus Presented with Intraoral Extension

Abhishek Singhvi  1 , Ashish Joshi  2
Affiliations
Case Reports

A Case of Amelanotic Malignant Melanoma of the Maxillary Sinus Presented with Intraoral Extension

Abhishek Singhvi et al. Malays J Med Sci. 2015 Sep.

Abstract

Melanoma of the sinonasal cavity has a high incidence of amelanotic presentation. Its diagnosis is difficult for clinicians and pathologists because of its hidden location and lack of pigmentation at the microscopic level. We reported a case of amelanotic melanoma of the maxillary sinus that showed aggressive extension to the oral cavity after extraction of the maxillary tooth. Histologically, the lesion resembled a plasmacytoid tumour. Diagnosis was made through the positive immunohistochemical staining for S100 and HMB-45.

Keywords: amelanotic melanoma; immunohistochemistry; maxillary sinus; oral cavity.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest None.

Figures

Figure 1
Figure 1
Intraoral examination revealed two large masses on the left hard palate and on the left buccal vestibule.
Figure 2
Figure 2
Axial MRI of the lesion showing a large invasive sinonasal mass centred in the left maxillary antrum.
Figure 3
Figure 3
Section showing the sheets of round plasmacytoid cells with mitotic activity. (Hematoxylin and eosin stain; 400× magnification).
Figure 4
Figure 4
Tumor cells showing positive immunohistochemical staining for HMB-45, (HMB-45; 100× magnification).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Nothani K, Shindoh M, Yamazaki Y, Nakamura H, Watanabe M, Kogoh T, et al. Amelanotic Malignant Melanomas of Oral Mucosa. Br J Oral Maxillofac Surg. 2002;40(3):195–200. - PubMed
    1. Gupta S, Pant MC, Husain N, Sundar S, Khan H. Primary Amelanotic Melanoma of the Nasal Cavity: A Case Report. Ear Nose Throat J. 2014;93(1):E12–4. - PubMed
    1. Marcus DM, Marcus RP, Prabhu RS, Owonikoko TK, Lawson DH, Switchenko J, et al. Rising Incidence of Mucosal Melanoma of the Head and Neck in the United States. J Skin Cancer. 2012;2012:231693. doi: 10.1155/2012/231693. - DOI - PMC - PubMed
    1. Baderca F, Vincze D, Balica N, Solovan C. Mucosa Melanomas in The Elderly: Challanging Cases and Review of the Literature. Clin Interv Aging. 2014;9:929–937. doi: 10.2147/CIA.S64361. - DOI - PMC - PubMed
    1. Seetharamu N, Ott PA, Pavlick AC. Mucosal Melanomas: A Case-Based Review of the literature. Oncologist. 2010;15(7):772–781. doi: 10.1634/theoncologist.2010-0067. - DOI - PMC - PubMed

Publication types

LinkOut - more resources