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Case Reports
. 2015 Sep;22(5):89-92.

A Case of Amelanotic Malignant Melanoma of the Maxillary Sinus Presented with Intraoral Extension

Abhishek Singhvi  1 , Ashish Joshi  2
Affiliations
Case Reports

A Case of Amelanotic Malignant Melanoma of the Maxillary Sinus Presented with Intraoral Extension

Abhishek Singhvi et al. Malays J Med Sci. 2015 Sep.

Abstract

Melanoma of the sinonasal cavity has a high incidence of amelanotic presentation. Its diagnosis is difficult for clinicians and pathologists because of its hidden location and lack of pigmentation at the microscopic level. We reported a case of amelanotic melanoma of the maxillary sinus that showed aggressive extension to the oral cavity after extraction of the maxillary tooth. Histologically, the lesion resembled a plasmacytoid tumour. Diagnosis was made through the positive immunohistochemical staining for S100 and HMB-45.

Keywords: amelanotic melanoma; immunohistochemistry; maxillary sinus; oral cavity.

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Conflict of interest statement

Conflict of Interest None.

Figures

Figure 1
Figure 1
Intraoral examination revealed two large masses on the left hard palate and on the left buccal vestibule.
Figure 2
Figure 2
Axial MRI of the lesion showing a large invasive sinonasal mass centred in the left maxillary antrum.
Figure 3
Figure 3
Section showing the sheets of round plasmacytoid cells with mitotic activity. (Hematoxylin and eosin stain; 400× magnification).
Figure 4
Figure 4
Tumor cells showing positive immunohistochemical staining for HMB-45, (HMB-45; 100× magnification).
See this image and copyright information in PMC

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