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Comparative Study
. 1987 Oct;104(10):490-2.

[Combined action of nucleosides and alpha-interferon in inhibiting the reproduction of the herpes simplex type-II virus]

[Article in Russian]
E V Temicheva, V V Malinovskaia, L S Manakhova, L L Mironova, G A Galegov
  • PMID: 2823929
Comparative Study

[Combined action of nucleosides and alpha-interferon in inhibiting the reproduction of the herpes simplex type-II virus]

[Article in Russian]
E V Temicheva et al. Biull Eksp Biol Med. 1987 Oct.

Abstract

Therapeutic effect of four combinations of antiherpetic chemical preparations--acyclovir (ACV), 9-beta-D-arabinofuranosyladenine (ARA-A) and E-5-(2-bromovinyl)-2'-desoxyuridine (BVDU)--has been studied. Mutual enhancement was observed in all the combinations studied, except for ACV and ARA-A combination, where partial antagonism was observed. ACV + BVDU was shown to be the most optimal combination, with the minimum inhibitory concentration (MIC) of BVDU decreasing 400-fold. A significant enhancement of nucleosides antiviral effect was noted when the human leucocyte interferon was used with the combinations. Along with synergistic effect during the interaction of alpha-interferon with ACV the antagonism in the combination of alpha-interferon with ARA-A was observed.

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