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Editorial
. 2017 Feb 21:5:10.
doi: 10.1186/s40425-017-0212-y. eCollection 2017.

Immunotherapy resistance: the answers lie ahead - not in front - of us

Miles C Andrews  1 , Jennifer A Wargo  1   2
Affiliations
Editorial

Immunotherapy resistance: the answers lie ahead - not in front - of us

Miles C Andrews et al. J Immunother Cancer. .

Abstract

Mechanisms of innate and adaptive resistance to checkpoint blockade immunotherapy are under intense investigation with a view to broadening the therapeutic potential of this form of treatment. In a recent manuscript by Zaretsky and colleagues, mutational events were identified that effectively crippled ongoing immunotherapy responses in patients treated with anti-PD-1 therapy. These results are discussed in the light of other recent and ongoing research efforts exploring both mutational and non-mutational resistance mechanisms, highlighting the critical translational importance of longitudinal tumor sampling.

Keywords: Checkpoint blockade; Interferon; Longitudinal biopsies; Resistance; T cell exclusion.

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Comment on

  • Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.
    Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, Saco J, Homet Moreno B, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez PJ, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher TN, Lo RS, Ribas A. Zaretsky JM, et al. N Engl J Med. 2016 Sep 1;375(9):819-29. doi: 10.1056/NEJMoa1604958. Epub 2016 Jul 13. N Engl J Med. 2016. PMID: 27433843 Free PMC article.

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