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. 1987 Oct;92(2):349-55.
doi: 10.1111/j.1476-5381.1987.tb11330.x.

Release of endogenous ATP during sympathetic nerve stimulation

M J Lew  1 , T D White
Affiliations

Release of endogenous ATP during sympathetic nerve stimulation

M J Lew et al. Br J Pharmacol. 1987 Oct.

Abstract

1 Vas deferens from guinea-pig was stimulated with a suction electrode and both contractions and release of endogenous ATP monitored 2 Release of ATP was tetrodotoxin-sensitive and increased when the number of stimuli was increased. 3 Release of ATP was not due to contraction of the muscle and persisted following block of contractions with prazosin and alpha, beta-methylene ATP. 4 These results indicate that stimulation of the sympathetic nerves in the vas deferens releases endogenous ATP presynaptically, supporting a cotransmitter function for ATP with noradrenaline.

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