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. 1987 Oct 13;423(1-2):173-8.
doi: 10.1016/0006-8993(87)90837-7.

The suprachiasmatic nuclei stimulate evening ACTH secretion in the rat

C S Cascio  1 , J Shinsako, M F Dallman
Affiliations

The suprachiasmatic nuclei stimulate evening ACTH secretion in the rat

C S Cascio et al. Brain Res. .

Abstract

The effect of bilateral lesions of the suprachiasmatic nuclei (SCN) on the circadian rhythm in ACTH was studied in rats that were adrenalectomized and implanted with a subcutaneous corticosterone (B) pellet. Rats wee chronically cannulated to allow for repeated blood sampling. In rats with B pellets, bilateral lesions of the SCN eliminated the circadian rise in plasma ACTH seen in sham-lesioned animals. This is consistent with the idea that the SCN stimulate ACTH secretion in the evening.

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