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Randomized Controlled Trial
. 2017 Jul;112(7):1238-1249.
doi: 10.1111/add.13802. Epub 2017 May 2.

Large multi-centre pilot randomized controlled trial testing a low-cost, tailored, self-help smoking cessation text message intervention for pregnant smokers (MiQuit)

Felix Naughton  1   2 , Sue Cooper  3   2 , Katharine Foster  3   2 , Joanne Emery  4   2 , Jo Leonardi-Bee  5   2 , Stephen Sutton  4   2 , Matthew Jones  3   2 , Michael Ussher  6   2 , Rachel Whitemore  3   2 , Matthew Leighton  7 , Alan Montgomery  7 , Steve Parrott  8   2 , Tim Coleman  3   2
Affiliations
Randomized Controlled Trial

Large multi-centre pilot randomized controlled trial testing a low-cost, tailored, self-help smoking cessation text message intervention for pregnant smokers (MiQuit)

Felix Naughton et al. Addiction. 2017 Jul.

Abstract

Aims: To estimate the effectiveness of pregnancy smoking cessation support delivered by short message service (SMS) text message and key parameters needed to plan a definitive trial.

Design: Multi-centre, parallel-group, single-blinded, individual randomized controlled trial.

Setting: Sixteen antenatal clinics in England.

Participants: Four hundred and seven participants were randomized to the intervention (n = 203) or usual care (n = 204). Eligible women were < 25 weeks gestation, smoked at least one daily cigarette (> 5 pre-pregnancy), were able to receive and understand English SMS texts and were not already using text-based cessation support.

Intervention: All participants received a smoking cessation leaflet; intervention participants also received a 12-week programme of individually tailored, automated, interactive, self-help smoking cessation text messages (MiQuit).

Outcome measurements: Seven smoking outcomes, including validated continuous abstinence from 4 weeks post-randomization until 36 weeks gestation, design parameters for a future trial and cost-per-quitter.

Findings: Using the validated, continuous abstinence outcome, 5.4% (11 of 203) of MiQuit participants were abstinent versus 2.0% (four of 204) of usual care participants [odds ratio (OR) = 2.7, 95% confidence interval (CI) = 0.93-9.35]. The Bayes factor for this outcome was 2.23. Completeness of follow-up at 36 weeks gestation was similar in both groups; provision of self-report smoking data was 64% (MiQuit) and 65% (usual care) and abstinence validation rates were 56% (MiQuit) and 61% (usual care). The incremental cost-per-quitter was £133.53 (95% CI = -£395.78 to 843.62).

Conclusions: There was some evidence, although not conclusive, that a text-messaging programme may increase cessation rates in pregnant smokers when provided alongside routine NHS cessation care.

Keywords: SMS text messaging; mHealth; pregnancy; randomized controlled trial; self-help; smoking cessation.

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Figures

Figure 1
Figure 1
Trial flow. *Includes 17 MiQuit participants without 4‐week follow up data; **includes 14 usual care participants without 4‐week follow‐up data
See this image and copyright information in PMC

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