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. 2017 Jan 1;18(1):87-91.
doi: 10.22034/APJCP.2017.18.1.87.

General Characteristics and Cytotoxic Effects of Nano-Poly (Butyl Cyanoacrylate) Containing Carboplatin on Ovarian Cancer Cells

Leila Kanaani  1 , Meysam Ebrahimi Far, S Maryam Kazemi, Edris Choupani, Maral Mazloumi Tabrizi, Hasan Ebrahimi Shahmabadi, Azim Akbarzadeh Khiyavi
Affiliations

General Characteristics and Cytotoxic Effects of Nano-Poly (Butyl Cyanoacrylate) Containing Carboplatin on Ovarian Cancer Cells

Leila Kanaani et al. Asian Pac J Cancer Prev. .

Abstract

The initial response to treatment and subsequent development of resistance to carboplatin are very important challenges. Use of nano drug delivery is a new method to replace standard chemotherapy. In this research, both non-PEGylated and PEGylated nanoparticles (NPs) were prepared by mini-emulsion polymerization of poly (butyl cyanoacrylate) (PBCA) NPs. Characteristics such as size, polydispersity index (PDI), zeta potential, drug release, and stability were examined. In addition, infrared spectroscopy was used for description of the produced NPs. Then, cytotoxicity effects of both formulations were studied on the A2780CIS ovarian cancer cell line with incubation for 24, 48, and 72h. Examination of characteristics of loaded carboplatin on the PBCA NPs under suitable laboratory conditions showed a positive effect of PEG on their properties. Cytotoxicity studies demonstrated greater toxicity with both formulations of nano-drugs than the free drug. The results indicated that PBCA NPs can be considered as suitable candidates for nano-drugs in chemotherapy.

Keywords: Ovarian cancer; carboplatin; poly (butyl Cyanoacrylate) nanoparticle; nano-drug delivery.

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Figures

Figure 1
Figure 1
Anionic Polymerization of Alkyl Cyanoacrylate Monomers Leading to the Formation of the Nanoparticles. The Hydroxyl Ions in the Water Start the Reaction
Figure 2
Figure 2
Infrared Spectra of PEGylated PBCA NPs
Figure 3
Figure 3
Pattern of Carboplatin Release of PBCA NPs (Blue and Red Lines are Relevant to the PEGylated and no-PEGylated Nano Drugs, Respectively)
Figure 4
Figure 4
Cytotoxicity Effects of Free Carboplatin and Loaded Carboplatin on the PBCA NPs in the A2780CIS Cell after 24h Incubation. (a) PEGylated NPs (P<0.05) and (b) no- PEGylated NPs (P<0.05)
Figure 5
Figure 5
Cytotoxicity Effects of Free Carboplatin and Loaded Carboplatin on the PBCA NPs in the A2780CIS Cell after 48h Incubation. (a) PEGylated NPs (P<0.05) and (b) no-PEGylated NPs (P<0.05)
Figure 6
Figure 6
Cytotoxicity Effects of Free Carboplatin and Loaded Carboplatin on the PBCA NPs in the A2780CIS Cell after 72h Incubation. (a) PEGylated NPs (P<0.05) and (b) no-PEGylated NPs (P<0.05)
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