Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017;44(1):40-50.
doi: 10.1159/000455060. Epub 2017 Feb 28.

Effects of Blood Purification on Serum Levels of Inflammatory Cytokines and Cardiac Function in a Rat Model of Sepsis

Cong-Meng Lin  1 , Cun-Rong Chen, Xue-Qiong Wu, Jin-Hua Ren, Shao-Zhen Chen, Xiao-Feng Luo, Xu-Qiao Mei, Lv-Ying Shen, Meng-Xian Guo, Xu-Dong Ma, Ting Yang
Affiliations

Effects of Blood Purification on Serum Levels of Inflammatory Cytokines and Cardiac Function in a Rat Model of Sepsis

Cong-Meng Lin et al. Blood Purif. 2017.

Retraction in

  • Retraction Statement.
    [No authors listed] [No authors listed] Blood Purif. 2024 Feb 12:1. doi: 10.1159/000537697. Online ahead of print. Blood Purif. 2024. PMID: 38346415 Review. No abstract available.

Abstract

Objective: The study aimed to explore the effects of blood purification (BP) on serum levels of inflammatory cytokines and cardiac function in a rat model of sepsis.

Methods: A rat model of sepsis was established by cecal ligation and puncture. All rats were divided into the normal control, sham operation, model, sham treatment, and BP treatment groups. Cardiac functions, inflammatory cytokines, myocardial enzymes, pathological score of cardiac muscle tissue, and myocardial apoptosis of rats in each group were compared.

Results: Sepsis rats had higher serum levels of inflammatory cytokines and lower cardiac function than those in the normal control and sham operation groups. Compared with the model and sham treatment groups, improved cardiac functions, decreased inflammatory cytokines, myocardial enzymes, pathological score, and myocardial apoptosis and mortality were observed in the BP treatment group.

Conclusion: BP may reduce serum levels of inflammatory cytokines and improve cardiac function of sepsis rats.

PubMed Disclaimer

Publication types

LinkOut - more resources