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Observational Study
. 2017 Feb 27;16(1):48.
doi: 10.1186/s12944-017-0436-3.

Association between Low-density lipoprotein cholesterol and occipital periventricular hyperintensities in a group of Chinese patients: an observational study

Dazhi Duan  1 , Lin Shen  2 , Chun Cui  3 , Tongsheng Shu  3 , Jian Zheng  2
Affiliations
Observational Study

Association between Low-density lipoprotein cholesterol and occipital periventricular hyperintensities in a group of Chinese patients: an observational study

Dazhi Duan et al. Lipids Health Dis. .

Abstract

Background: While occipital periventricular hyperintensities (OPVHs) are among the most common mild white matter hyperintensities, the clinical factors associated with OPVHs remain unclear. In this study, we investigated the role of clinical factors in development of pure OPVHs.

Methods: This study included 97 patients with OPVHs and 73 healthy controls. Univariate analysis of clinical factors in OPVH patients and controls was followed by binomial logistic regression analysis to identify clinical factors significantly associated with OPVHs.

Result: Univariate analysis indicated that age, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein-B (Apo-B) levels differed significantly between the OPVH patients and controls (p < 0.05). Age and gender were correlated with OPVH scores (p < 0.05), while LDL-C, triglycerides, Apo-B and TC were anti-correlated with OPVHs scores (p < 0.05). Multivariate analysis indicated that LDL-C is negatively correlated with OPVHs (p < 0.05), and age is positively correlated with OPVHs (p < 0.001).

Conclusion: In summary, LDL-C was negatively and age was positively associated with OPVHs among Chinese patients in a hospital.

Keywords: Cardiovascular risk factor; Low-density lipoprotein cholesterol; MRI; Occipital periventricular hyperintensities; White matter hyperintensity.

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Figures

Fig. 1
Fig. 1
Typical T2-weighted MRI images a control and a OPVHs patient. Two typical T2-weighted MRI images of a control (a) and a OPVHs patient (b). High-signal intensities are observed on the T2-weighted image of the OPVHs patient. In addition, no cerebral infarcts were observed on the T2-weighted images in any subjects
Fig. 2
Fig. 2
Receiver operating characteristic curve using age and LDL-C as diagnostic factors for OPVHs. ROC were obtained using OPVHs as positive outcome and age and LDL-C as diagnostic factors. It should be noted that the diagnostic strength of LDL-C, calculated using on the area under the curve, was greater than that of age for OPVHs
See this image and copyright information in PMC

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