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Case Reports
. 2017 Feb 27:2017:bcr2016218459.
doi: 10.1136/bcr-2016-218459.

Antithyroid arthritis syndrome

Anar Modi  1 , Hari Amin  2 , Farah Morgan  1
Affiliations
Case Reports

Antithyroid arthritis syndrome

Anar Modi et al. BMJ Case Rep. .

Abstract

Antithyroid arthritis syndrome is a constellation of symptoms of myalgia, arthralgia, arthritis, fever and rash associated with the use of antithyroid medications. We report a case of a patient with severe hyperthyroidism likely secondary to Graves' disease who presented with the abovementioned symptoms after being treated with methimazole (antithyroid medication). Our aim is to increase awareness regarding this uncommon but disabilitating and life-threatening adverse effect of antithyroid medications among clinicians. We also discuss the proposed pathophysiology for this immunological reaction as well as management options in these patients.

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Conflict of interest statement

Competing interests: None declared.

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References

    1. Bajaj S, Bell MJ, Shumak S et al. . Anti-thyroid arthritis syndrome. J Rheumatol 1998;25:1235–9. - PubMed
    1. Shabtai R, Shapiro MS, Orenstein D et al. . The anti-thyroid arthritis syndrome reviewed. Arthritis Rheum 1984;27:227–9. 10.1002/art.1780270216 - DOI - PubMed
    1. Wing SS, Fantus IG. Adverse immunologic effects of antithyroid drugs. CMAJ 1987;136:121–7. - PMC - PubMed
    1. Searle RP, Plymate SR, Troup GM. Familial thionamide induced lupus syndrome in thyrotoxicosis. J Rheumatol 1981;8:498–500. - PubMed
    1. Richard A, Walzer MD, Julia Einbinder MS. Immunoleukopenia as an aspect of hypersensitivity to propylthiouracil. JAMA 1963;184:743–6. - PubMed

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