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Review
. 2017:2017:6404638.
doi: 10.1155/2017/6404638. Epub 2017 Jan 24.

PPAR γ and Its Role in Cardiovascular Diseases

Mini Chandra  1 , Sumitra Miriyala  1 , Manikandan Panchatcharam  1
Affiliations
Review

PPAR γ and Its Role in Cardiovascular Diseases

Mini Chandra et al. PPAR Res. 2017.

Abstract

Peroxisome proliferator-activated receptor Gamma (PPARγ), a ligand-activated transcription factor, has a role in various cellular functions as well as glucose homeostasis, lipid metabolism, and prevention of oxidative stress. The activators of PPARγ are already widely used in the treatment of diabetes mellitus. The cardioprotective effect of PPARγ activation has been studied extensively over the years making them potential therapeutic targets in diseases associated with cardiovascular disorders. However, they are also associated with adverse cardiovascular events such as congestive heart failure and myocardial infarction. This review aims to discuss the role of PPARγ in the various cardiovascular diseases and summarize the current knowledge on PPARγ agonists from multiple clinical trials. Finally, we also review the new PPARγ agonists under development as potential therapeutics with reduced or no adverse effects.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
(a) Phosphorylation of PPARγ by ERK and CDK5 which also suppresses ERK Kinase. (b) TZD blocking the access of ERK and CDK5.
Figure 2
Figure 2
PPARγ suppresses the activation of NF-κB decreasing its inflammatory effects.
See this image and copyright information in PMC

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