doi: 10.1007/s10517-017-3640-2.
Epub 2017 Feb 27.
Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran
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- PMID: 28243911
- DOI: 10.1007/s10517-017-3640-2
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Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran
Bull Exp Biol Med.
2017 Feb.
Abstract
Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.
Keywords: anticoagulant activity; dextran; dextran sulfate.
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