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Comment
. 2017 Apr;27(4):459-460.
doi: 10.1038/cr.2017.27. Epub 2017 Feb 28.

Cancer: a new role for non-canonical Hippo signaling

Jonathan Cooper  1 , Filippo G Giancotti  2
Affiliations
Comment

Cancer: a new role for non-canonical Hippo signaling

Jonathan Cooper et al. Cell Res. 2017 Apr.

Abstract

The molecular mechanisms governing self-renewal and differentiation of the mammary epithelium are incompletely defined; a better understanding of the events implicated in the specification and expansion of luminal progenitors is of particular importance as many breast cancers originate from their transformation. Britschgi et al. found that, in addition to phosphorylating and inactivating YAP, LATS functions as a scaffold to facilitate estrogen receptor-α ubiquitylation by the E3 ligase CRL4 and consequently suppresses luminal progenitor specification and expansion.

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Figures

Figure 1
Figure 1
CRL4DCAF1-mediated ERα degradation in different cellular contexts.
See this image and copyright information in PMC

Comment on

  • The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα.
    Britschgi A, Duss S, Kim S, Couto JP, Brinkhaus H, Koren S, De Silva D, Mertz KD, Kaup D, Varga Z, Voshol H, Vissieres A, Leroy C, Roloff T, Stadler MB, Scheel CH, Miraglia LJ, Orth AP, Bonamy GM, Reddy VA, Bentires-Alj M. Britschgi A, et al. Nature. 2017 Jan 26;541(7638):541-545. doi: 10.1038/nature20829. Epub 2017 Jan 9. Nature. 2017. PMID: 28068668 Free PMC article.

References

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    1. Britschgi A, Duss S, Kim S, et al. Nature 2017; 541:541–545. - PMC - PubMed

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