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. 1987 Nov 25;262(33):16032-6.

Organization of the human pro-alpha 2(I) collagen gene

W de Wet  1 , M Bernard, V Benson-Chanda, M L Chu, L Dickson, D Weil, F Ramirez
Affiliations
  • PMID: 2824475
Free article

Organization of the human pro-alpha 2(I) collagen gene

W de Wet et al. J Biol Chem. .
Free article

Abstract

Sixty kilobases of cloned DNA containing the entire human pro-alpha 2(I) collagen gene and 22 kilobases of flanking sequences have been isolated. Like the homologous avian gene, the 1366 amino acid residues of the human pre-pro-alpha 2(I) chain are encoded by 52 exons, whose relative locations and sizes have been determined. Analysis of the 5'- and 3'-untranslated regions have confirmed their exact lengths, as well as conclusively established the nature of five polymorphic mRNA transcripts.

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