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Review
. 2017:48:84-96.
doi: 10.1159/000452908. Epub 2017 Feb 28.

Leptin, Neuroinflammation and Obesity

Nathalia R V Dragano, Roberta Haddad-Tovolli, Licio A Velloso
Review

Leptin, Neuroinflammation and Obesity

Nathalia R V Dragano et al. Front Horm Res. 2017.

Abstract

Hypothalamic resistance to adipostatic actions of leptin is a hallmark of obesity. Studies have revealed that hypothalamic inflammation, triggered in response to the consumption of large amounts of dietary fat, is an important mechanism in the development of leptin resistance. In this chapter, we will review the work that paved the way linking neuroinflammation of the hypothalamus and defective leptin action in obesity.

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