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Review
. 2017 Feb 26;22(3):358.
doi: 10.3390/molecules22030358.

Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome

Jesús Santana-Gálvez  1 , Luis Cisneros-Zevallos  2 , Daniel A Jacobo-Velázquez  3
Affiliations
Review

Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome

Jesús Santana-Gálvez et al. Molecules. .

Abstract

Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from thehydroxycinnamic acid family. This polyphenol possesses many health-promoting properties, mostof them related to the treatment of metabolic syndrome, including anti-oxidant, anti-inflammatory,antilipidemic, antidiabetic, and antihypertensive activities. The first part of this review will discussthe role of chlorogenic acid as a nutraceutical for the prevention and treatment of metabolicsyndrome and associated disorders, including in vivo studies, clinical trials, and mechanisms ofaction. The second part of the review will be dealing with the role of chlorogenic acid as a foodadditive. Chlorogenic acid has shown antimicrobial activity against a wide range of organisms,including bacteria, yeasts, molds, viruses, and amoebas. These antimicrobial properties can beuseful for the food industry in its constant search for new and natural molecules for thepreservation of food products. In addition, chlorogenic acid has antioxidant activity, particularlyagainst lipid oxidation; protective properties against degradation of other bioactive compoundspresent in food, and prebiotic activity. The combination of these properties makes chlorogenic acidan excellent candidate for the formulation of dietary supplements and functional foods.

Keywords: 5-O-caffeoylquinic acid; antibiotic; antioxidant; chlorogenic acid; metabolic syndrome; prebiotic.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of chlorogenic acid (5-O-caffeoylquinic acid).
Figure 2
Figure 2
Proposed model for preventive and therapeutic effects of chlorogenic acid (A) or chlorogenic acid-rich foods and supplements (B) over metabolic syndrome based on in vivo studies (*) and clinical studies (**).
Figure 3
Figure 3
Mechanisms of action of chlorogenic acid over metabolic syndrome. Abbreviations: ACC = acetyl-CoA carboxylase, AMPK = AMP-activated protein kinase, FAS = fatty acid synthase, FFA = free fatty acid, G-6-P = glucose-6-phosphatase, HMGCR = 3-hydroxy-3-methylglutaryl CoA reductase, LXRα = liver X receptor α, NO = nitric oxide, PPARα = peroxisome proliferator-activated receptor α, PPARγ = peroxisome proliferator-activated receptor γ, ROS = reactive oxygen species.
See this image and copyright information in PMC

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