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Review
. 2017 Feb 26;14(3):232.
doi: 10.3390/ijerph14030232.

Toxicity Research of PM2.5 Compositions In Vitro

Yi-Yang Jia  1 , Qi Wang  2 , Te Liu  3
Affiliations
Review

Toxicity Research of PM2.5 Compositions In Vitro

Yi-Yang Jia et al. Int J Environ Res Public Health. .

Abstract

According to the published literature, we surmise that particulate matter (PM) concentration, individually, may be less important than components in explaining health effects. PM2.5 (aerodynamic diameter <2.5 μm) had similar cytotoxicity (e.g., cell viability reduction, oxidative damage, inflammatory effects and genetic toxicity) on different types of cells. The studies of cells are readily available for detailed mechanistic investigations, which is more appropriate for learning and comparing the mechanism caused by single or mixed ingredients coating a carbon core. No review exists that holistically examines the evidence from all components-based in vitro studies. We reviewed published studies that focus on the cytotoxicity of normal PM2.5. Those studies suggested that the toxicity of mixed compositions differs greatly from the single ingredients in mixed components and the target cells. The cytotoxic responses caused by PM2.5 components have not shown a consistent association with clear, specific health effects. The results may be beneficial for providing new targets for drugs for the treatment of PM2.5-related diseases.

Keywords: cell; components; health; particular matter; toxicology.

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Conflict of interest statement

The authors declare no conflicts of interest.

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References

    1. Gualtieri M., Mantecca P., Corvaja V., Longhin E., Perrone M.G., Bolzacchini E., Camatini M. Winter fine particulate matter from milan induces morphological and functional alterations in human pulmonary epithelial cells (a549) Toxicol. Lett. 2009;188:52–62. doi: 10.1016/j.toxlet.2009.03.003. - DOI - PubMed
    1. Oberdörster G., Oberdörster E., Oberdörster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005;113:823–839. doi: 10.1289/ehp.7339. - DOI - PMC - PubMed
    1. Lippmann M., Schlesinger R.B. Toxicological bases for the setting of health-related air pollution standards. Annu. Rev. Public Health. 2000;21:309–333. doi: 10.1146/annurev.publhealth.21.1.309. - DOI - PubMed
    1. Baulig A., Poirault J.J., Ausset P., Schins R., Shi T., Baralle D., Dorlhene P., Meyer M., Lefevre R., Baeza-Squiban A., et al. Physicochemical characteristics and biological activities of seasonal atmospheric particulate matter sampling in two locations of paris. Environ. Sci. Technol. 2004;38:5985–5992. doi: 10.1021/es049476z. - DOI - PubMed
    1. Alfaro-Moreno E., Nawrot T.S., Vanaudenaerde B.M., Hoylaerts M.F., Vanoirbeek J.A., Nemery B., Hoet P.H. Co-cultures of multiple cell types mimic pulmonary cell communication in response to urban PM10. Eur. Respir. J. 2008;32:1184–1194. doi: 10.1183/09031936.00044008. - DOI - PubMed

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