The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex
- PMID: 28246558
- PMCID: PMC5299163
- DOI: 10.1155/2017/6871089
The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex
Abstract
Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in depression. The changes in neural plasticity induced by stress and other negative stimuli play a significant role in the onset and development of depression. Antidepressant treatments have also been found to exert their antidepressant effects through regulatory effects on neural plasticity. However, the detailed mechanisms of neural plasticity in depression still remain unclear. Therefore, in this review, we summarize the recent literature to elaborate the possible mechanistic role of neural plasticity in depression. Taken together, these findings may pave the way for future progress in neural plasticity studies.
Conflict of interest statement
The authors confirm that this article content has no conflict of interests.
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