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Review
. 2017:1556:3-19.
doi: 10.1007/978-1-4939-6771-1_1.

Muscle Stem Cells: A Model System for Adult Stem Cell Biology

Ddw Cornelison  1 , Eusebio Perdiguero  2
Affiliations
Review

Muscle Stem Cells: A Model System for Adult Stem Cell Biology

Ddw Cornelison et al. Methods Mol Biol. 2017.

Abstract

Skeletal muscle stem cells, originally termed satellite cells for their position adjacent to differentiated muscle fibers, are absolutely required for the process of skeletal muscle repair and regeneration. In the last decade, satellite cells have become one of the most studied adult stem cell systems and have emerged as a standard model not only in the field of stem cell-driven tissue regeneration but also in stem cell dysfunction and aging. Here, we provide background in the field and discuss recent advances in our understanding of muscle stem cell function and dysfunction, particularly in the case of aging, and the potential involvement of muscle stem cells in genetic diseases such as the muscular dystrophies.

Keywords: Aging; Heterogeneity; Muscle regeneration; Muscular dystrophies; Skeletal muscle; Stem cells.

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References

    1. Till JE, McCulloch CE (1961) A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213–222 - DOI - PubMed
    1. Till JE, Mak TW, Price GB, Senn JS, McCulloch EA (1976) Cellular subclasses in human leukemic hemopoiesis. Hamatol Bluttransfus 19:33–45 - PubMed
    1. Sabin FR, Doan CA, Forkner CE (1932) The production of osteogenic sarcomata and the effects on lymph nodes and bone marrow of intravenous injections of radium chloride and mesothorium in rabbits. J Exp Med 56(2):267–289 - DOI - PubMed - PMC
    1. Ramalho-Santos M, Willenbring H (2007) On the origin of the term “stem cell”. Cell Stem Cell 1(1):35–38. doi: 10.1016/j.stem.2007.05.013 - DOI - PubMed
    1. Becker AJ, McCulloch CE, Till JE (1963) Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 197:452–454 - DOI - PubMed

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