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Review
. 2017:1556:129-147.
doi: 10.1007/978-1-4939-6771-1_7.

Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle

Francesco Saverio Tedesco #  1 , Louise A Moyle #  2 , Eusebio Perdiguero #  3
Affiliations
Review

Muscle Interstitial Cells: A Brief Field Guide to Non-satellite Cell Populations in Skeletal Muscle

Francesco Saverio Tedesco et al. Methods Mol Biol. 2017.

Abstract

Skeletal muscle regeneration is mainly enabled by a population of adult stem cells known as satellite cells. Satellite cells have been shown to be indispensable for adult skeletal muscle repair and regeneration. In the last two decades, other stem/progenitor cell populations resident in the skeletal muscle interstitium have been identified as "collaborators" of satellite cells during regeneration. They also appear to have a key role in replacing skeletal muscle with adipose, fibrous, or bone tissue in pathological conditions. Here, we review the role and known functions of these different interstitial skeletal muscle cell types and discuss their role in skeletal muscle tissue homeostasis, regeneration, and disease, including their therapeutic potential for cell transplantation protocols.

Keywords: Fibro-adipogenic progenitors; Interstitial cells; Mesenchymal progenitors; Mesoangioblasts; Muscle regeneration; Pericytes; Pw1; Skeletal muscle; Stem cells.

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