Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies

doi:10.1097/PCC.0000000000001050

Review

. 2017 Mar;18(3_suppl Suppl 1):S24-S31.

doi: 10.1097/PCC.0000000000001050.

Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies

Katri V Typpo¹, Hector R Wong, Stacey D Finley, Rodney C Daniels, Andrew J E Seely, Jacques Lacroix

Affiliations

Affiliation

¹ 1Department of Pediatrics and the Steele Children's Research Center, University of Arizona College of Medicine-Tucson, Tucson, AZ. 2Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH. 3Biomedical Engineering Department, Viterbi School of Engineering, University of Southern California, Los Angeles, CA. 4Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, and Department of Biomedical Engineering, Michigan Center for Integrated Research in Critical Care, University of Michigan, Ann Arbor, MI. 5Division of Thoracic Surgery and Critical Care Medicine, Department of Surgery, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. 6Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Montréal, QC, Canada.

PMID: 28248831
PMCID: PMC5333164
DOI: 10.1097/PCC.0000000000001050

Review

Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies

Katri V Typpo et al. Pediatr Crit Care Med. 2017 Mar.

. 2017 Mar;18(3_suppl Suppl 1):S24-S31.

doi: 10.1097/PCC.0000000000001050.

Authors

Katri V Typpo¹, Hector R Wong, Stacey D Finley, Rodney C Daniels, Andrew J E Seely, Jacques Lacroix

Affiliation

¹ 1Department of Pediatrics and the Steele Children's Research Center, University of Arizona College of Medicine-Tucson, Tucson, AZ. 2Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH. 3Biomedical Engineering Department, Viterbi School of Engineering, University of Southern California, Los Angeles, CA. 4Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, and Department of Biomedical Engineering, Michigan Center for Integrated Research in Critical Care, University of Michigan, Ann Arbor, MI. 5Division of Thoracic Surgery and Critical Care Medicine, Department of Surgery, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. 6Division of Pediatric Critical Care Medicine, Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Montréal, QC, Canada.

PMID: 28248831
PMCID: PMC5333164
DOI: 10.1097/PCC.0000000000001050

Abstract

Objective: To describe new technologies (biomarkers and tests) used to assess and monitor the severity and progression of multiple organ dysfunction syndrome in children as discussed as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26-27, 2015).

Data sources: Literature review, research data, and expert opinion.

Study selection: Not applicable.

Data extraction: Moderated by an experienced expert from the field, investigators developing and assessing new technologies to improve the care and understanding of critical illness presented their research and the relevant literature.

Data synthesis: Summary of presentations and discussion supported and supplemented by relevant literature.

Conclusions: There are many innovative tools and techniques with the potential application for the assessment and monitoring of severity of multiple organ dysfunction syndrome. If the reliability and added value of these candidate technologies can be established, they hold promise to enhance the understanding, monitoring, and perhaps, treatment of multiple organ dysfunction syndrome in children.

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Conflict of interest statement

Conflict of interest

Andrew Seely has patents related to continuous multiorgan variability analysis, and is Founder and Chief Science Officer of Therapeutic Monitoring Systems, a company created to help bring variability-derived clinical decision support to the bedside to improve care. The other authors did not have any conflict to declare.

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References

1. Wong HR. Genome-wide expression profiling in pediatric septic shock. Pediatr Res. 2013;73:564–569. - PMC - PubMed
1. Wong HR, Salisbury S, Xiao Q, et al. The pediatric sepsis biomarker risk model. Crit Care. 2012;16:R174. - PMC - PubMed
1. Alder MN, Lindsell CJ, Wong HR. The pediatric sepsis biomarker risk model: Potential implications for sepsis therapy and biology. Expert Rev Anti Infect Ther. 2014;12:809–816. - PMC - PubMed
1. Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med. 2011;12:165–173. - PMC - PubMed
1. Wong HR, Weiss SL, Giuliano JS, et al. Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model. PLoS One. 2014;9:e86242. - PMC - PubMed

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[1] Wong HR. Genome-wide expression profiling in pediatric septic shock. Pediatr Res. 2013;73:564–569. - PMC - PubMed

[2] Wong HR. Genome-wide expression profiling in pediatric septic shock. Pediatr Res. 2013;73:564–569. - PMC - PubMed

[3] Wong HR, Salisbury S, Xiao Q, et al. The pediatric sepsis biomarker risk model. Crit Care. 2012;16:R174. - PMC - PubMed

[4] Wong HR, Salisbury S, Xiao Q, et al. The pediatric sepsis biomarker risk model. Crit Care. 2012;16:R174. - PMC - PubMed

[5] Alder MN, Lindsell CJ, Wong HR. The pediatric sepsis biomarker risk model: Potential implications for sepsis therapy and biology. Expert Rev Anti Infect Ther. 2014;12:809–816. - PMC - PubMed

[6] Alder MN, Lindsell CJ, Wong HR. The pediatric sepsis biomarker risk model: Potential implications for sepsis therapy and biology. Expert Rev Anti Infect Ther. 2014;12:809–816. - PMC - PubMed

[7] Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med. 2011;12:165–173. - PMC - PubMed

[8] Kaplan JM, Wong HR. Biomarker discovery and development in pediatric critical care medicine. Pediatr Crit Care Med. 2011;12:165–173. - PMC - PubMed

[9] Wong HR, Weiss SL, Giuliano JS, et al. Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model. PLoS One. 2014;9:e86242. - PMC - PubMed

[10] Wong HR, Weiss SL, Giuliano JS, et al. Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model. PLoS One. 2014;9:e86242. - PMC - PubMed

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Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies

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Monitoring Severity of Multiple Organ Dysfunction Syndrome: New Technologies

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