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. 2017 Mar 1;17(1):71.
doi: 10.1186/s12872-017-0502-9.

High levels of serum β2-microglobulin predict severity of coronary artery disease

Ling You  1 , Ruiqin Xie  1 , Haijuan Hu  1 , Guoqiang Gu  1 , Hongmei Zheng  1 , Jidong Zhang  1 , Xiaohong Yang  1 , Ximiao He  2 , Wei Cui  3
Affiliations

High levels of serum β2-microglobulin predict severity of coronary artery disease

Ling You et al. BMC Cardiovasc Disord. .

Abstract

Background: The identification of new risk factors for coronary artery disease (CAD) is increasingly sought in an effort to tackle this threatening disease. β2-microglobulin (B2M) is reported to associate with peripheral arterial disease and adverse cardiovascular outcomes. However, the association between B2M and cardiovascular disease remains under-researched. This study evaluated the effects of B2M on CAD without renal dysfunction.

Methods: One thousand seven hundred sixty-two subjects (403 non-CAD subjects and 1,359 CAD subjects) were investigated. Fasting samples were collected to determine B2M level. The Gensini and SYNTAX scores were used to assess the severity of CAD.

Results: CAD subjects were significantly higher in serum B2M level comparing with non-CAD subjects (1.25 ± 0.46 vs 1.14 ± 0.28 mg/L, p < 0.001). Serum B2M level was a risk factor of CAD after adjusting potential confounders (Odds Ratio (OR) = 2.363, 95% confidence interval (CI): 1.467-3.906, p = 0.001). Receiver operating characteristics (ROC) showed B2M level moderately predicted diagnosis of CAD (the area under the ROC curve (AUC) = 0.608, 95% CI: 0.577-0.639, p < 0.001). Furthermore, serum B2M level was positively associated with Gensini score system, SYNTAX score system and the number of disease vessels (NDV ≥ 2).

Conclusions: The significant association between serum B2M and CAD suggests that B2M could be a biomarker for CAD.

Keywords: Coronary artery disease; Severity; β2-Microglobulin.

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Figures

Fig. 1
Fig. 1
B2M levels between patients with CAD (n = 1,359) and those without CAD (n = 403). a Comparison of serum B2M levels in non-CAD vs CAD. b Comparison of serum B2M levels according to the number of stenotic coronary arteries (NVD = 0, 1, 2, and 3)
Fig. 2
Fig. 2
Bar graphs show the prevalence of CAD (a) and severe CAD (b) according to B2M quartiles
Fig. 3
Fig. 3
ROC curve analyses for predictive values of B2M in detecting CAD
Fig. 4
Fig. 4
Correlation between B2M and the severity of CAD evaluated by either (a) Gensini or (b) SYNTAX score
See this image and copyright information in PMC

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