Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 May;55(5):1269-1275.
doi: 10.1128/JCM.00017-17. Epub 2017 Mar 1.

Whole-Genome Sequencing in Epidemiology of Campylobacter jejuni Infections

Ann-Katrin Llarena  1 , Eduardo Taboada  2 , Mirko Rossi  3
Affiliations
Review

Whole-Genome Sequencing in Epidemiology of Campylobacter jejuni Infections

Ann-Katrin Llarena et al. J Clin Microbiol. 2017 May.

Abstract

This review describes the current state of knowledge regarding the application of whole-genome sequencing (WGS) in the epidemiology of Campylobacter jejuni, the leading cause of bacterial gastroenteritis worldwide. We describe how WGS has increased our understanding of the evolutionary and epidemiological dynamics of this pathogen and how WGS has the potential to improve surveillance and outbreak detection. We have identified hurdles to the full implementation of WGS in public health settings. Despite these challenges, we think that ample evidence is available to support the benefits of integrating WGS into the routine monitoring of C. jejuni infections and outbreak investigations.

Keywords: foodborne pathogens; genome analysis; molecular subtyping; surveillance studies.

PubMed Disclaimer

References

    1. Carrillo CD, Kruczkiewicz P, Mutschall S, Tudor A, Clark C, Taboada EN. 2012. A framework for assessing the concordance of molecular typing methods and the true strain phylogeny of Campylobacter jejuni and C. coli using draft genome sequence data. Front Cell Infect Microbiol 2:57. - PMC - PubMed
    1. Köser CU, Ellington MJ, Cartwright EJP, Gillespie SH, Brown NM, Farrington M, Holden MTG, Dougan G, Bentley SD, Parkhill J, Peacock SJ. 2012. Routine use of microbial whole genome sequencing in diagnostic and public health microbiology. PLoS Pathog 8:e1002824. doi:10.1371/journal.ppat.1002824. - DOI - PMC - PubMed
    1. Inns T, Ashton PM, Herrera-Leon S, Lighthill J, Foulkes S, Jombart T, Rehman Y, Fox A, Dallman T, Pinna ED, Browning L, Coia JE, Edeghere O, Vivancos R. 2017. Prospective use of whole genome sequencing (WGS) detected a multi-country outbreak of Salmonella Enteritidis. Epidemiol Infect 145:289–298. doi:10.1017/S0950268816001941. - DOI - PMC - PubMed
    1. Kaakoush NO, Castaño-Rodríguez N, Mitchell HM, Man SM. 2015. Global epidemiology of Campylobacter infection. Clin Microbiol Rev 28:687–720. doi:10.1128/CMR.00006-15. - DOI - PMC - PubMed
    1. Biggs PJ, Fearnhead P, Hotter G, Mohan V, Collins-Emerson J, Kwan E, Besser TE, Cookson A, Carter PE, French NP. 2011. Whole-genome comparison of two Campylobacter jejuni isolates of the same sequence type reveals multiple loci of different ancestral lineage. PLoS One 6:e27121. doi:10.1371/journal.pone.0027121. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources