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. 2017 Jan;12(1):64-65.
doi: 10.4103/1673-5374.198980.

Insights into the protective role of immunity in neurodegenerative disease

Cristoforo Comi  1 , Giacomo Tondo  2
Affiliations

Insights into the protective role of immunity in neurodegenerative disease

Cristoforo Comi et al. Neural Regen Res. 2017 Jan.
No abstract available

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Figures

Figure 1
Figure 1
The main players of neuroprotective inflammation. The figure shows the main cell types involved in protective pathways counteracting neurodegeneration: microglia, astrocytes, T-reg cells, complement system. Intercellular cross talk, as well as down-modulation of detrimental inflammatory reactions is essentially mediated by cytokines, including interleukin 1 receptor antagonist (IL1ra), interleukin 10 (IL10) and interleukin 4 (IL4), transforming growth factor beta (TGFβ), and osteopontin (OPN). Also other soluble molecules with growth factor properties, such as growth arrest specific 6 (Gas6), may contribute to neuroprotection.
See this image and copyright information in PMC

References

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