Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017:2017:5693501.
doi: 10.1155/2017/5693501. Epub 2017 Jan 30.

Idiopathic Pulmonary Hemosiderosis in a Child with Recurrent Macrophage Activation Syndrome Secondary to Systemic Juvenile Idiopathic Arthritis

Kenan Barut  1 , Sezgin Sahin  1 , Amra Adrovic  1 , Velat Sen  2 , Ozgur Kasapcopur  1
Affiliations
Case Reports

Idiopathic Pulmonary Hemosiderosis in a Child with Recurrent Macrophage Activation Syndrome Secondary to Systemic Juvenile Idiopathic Arthritis

Kenan Barut et al. Case Rep Pediatr. 2017.

Abstract

Macrophage activation syndrome, a severe complication of systemic juvenile idiopathic arthritis and other inflammatory diseases, represents one of the most important rheumatological emergencies. Delayed diagnosis could lead to life-threatening complications. Pulmonary hemosiderosis has been classically characterized by a triad of anemia, hemoptysis, and lung infiltrates on chest radiogram. Although the majority of patients of pulmonary hemosiderosis are considered idiopathic, secondary hemosiderosis associated with known diseases could be seen. In this case report, we aimed to present gradually increased pulmonary manifestations due to pulmonary hemosiderosis with recurrent macrophage activation syndrome attacks in a child with systemic juvenile idiopathic arthritis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interests.

Figures

Figure 1
Figure 1
Bilateral lung interstitial infiltration in chest radiography.
Figure 2
Figure 2
Bilateral diffuse fibrous changes and reticulonodular opacities in chest tomogram.
See this image and copyright information in PMC

References

    1. Barut K., Yücel G., Sinoplu A. B., Şahin S., Adroviç A., Kasapçopur Ö. Evaluation of macrophage activation syndrome associated with systemic juvenile idiopathic arthritis: single center experience over a one-year period. Turkish Archives of Pediatrics. 2015;50(4):206–210. doi: 10.5152/turkpediatriars.2015.3299. - DOI - PMC - PubMed
    1. Schulert G. S., Grom A. A. Pathogenesis of macrophage activation syndrome and potential for cytokine-directed therapies. Annual Review of Medicine. 2015;66:145–159. doi: 10.1146/annurev-med-061813-012806. - DOI - PMC - PubMed
    1. Minoia F., Davì S., Horne A., et al. Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients. Arthritis and Rheumatology. 2014;66(11):3160–3169. doi: 10.1002/art.38802. - DOI - PubMed
    1. Bakalli I., Kota L., Sala D., et al. Idiopathic pulmonary hemosiderosis—a diagnostic challenge. Italian Journal of Pediatrics. 2014;40, article 35 doi: 10.1186/1824-7288-40-35. - DOI - PMC - PubMed
    1. Ioachimescu O. C., Sieber S., Kotch A. Idiopathic pulmonary haemosiderosis revisited. European Respiratory Journal. 2004;24(1):162–170. doi: 10.1183/09031936.04.00116302. - DOI - PubMed

Publication types

LinkOut - more resources