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Review
. 2017:2017:6494795.
doi: 10.1155/2017/6494795. Epub 2017 Jan 31.

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Chang Xia  1 , Xiaoquan Rao  2 , Jixin Zhong  2
Affiliations
Review

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation

Chang Xia et al. J Diabetes Res. 2017.

Abstract

Although a critical role of adaptive immune system has been confirmed in driving local and systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying mechanism is not completely understood. Inflammatory regulation has been focused on innate immunity especially macrophage for a long time, while increasing evidence suggests T cells are crucial for the development of metabolic inflammation and insulin resistance since 2009. There was growing evidence supporting the critical implication of T cells in the pathogenesis of type 2 diabetes. We will discuss the available effect of T cells subsets in adaptive immune system associated with the procession of T2DM, which may unveil several potential strategies that could provide successful therapies in the future.

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Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

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