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. 1987 Nov;84(22):7827-31.
doi: 10.1073/pnas.84.22.7827.

Capsid protein VP4 of poliovirus is N-myristoylated

A V Paul  1 , A Schultz, S E Pincus, S Oroszlan, E Wimmer
Affiliations

Capsid protein VP4 of poliovirus is N-myristoylated

A V Paul et al. Proc Natl Acad Sci U S A. 1987 Nov.

Abstract

Poliovirus was labeled in vivo with [3H]myristic acid. Analysis of the capsid polypeptides revealed that the [3H]myristic acid residues copurified with VP4, the smallest and internal capsid protein of the virion. Evidence is presented showing unambiguously that the N-terminal glycine residue of VP4 is N-myristoylated. A previous analysis of the tryptic peptides of VP4 [Dorner, A. J., Dorner, L. F., Larsen, G. R., Wimmer, E. & Anderson, C. W. (1982) J. Virol. 42, 1017-1028] had shown that the N-terminal blocking group exists on all VP4 molecules as well as on VP0 and P1, two precursor polypeptides to VP4 in poliovirus. The possible function of the myristic acid residue in VP4 and in its precursor in poliovirus proliferation is discussed.

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References

    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. EMBO J. 1985 May;4(5):1145-52 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Mar;75(3):1404-8 - PubMed
    1. Nature. 1981 Jun 18;291(5816):547-53 - PubMed
    1. Microbiol Rev. 1981 Jun;45(2):287-315 - PubMed

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