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. 1987 Dec;84(23):8535-9.
doi: 10.1073/pnas.84.23.8535.

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

M C Carroll  1 , P Katzman, E M Alicot, B H Koller, D E Geraghty, H T Orr, J L Strominger, T Spies
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Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

M C Carroll et al. Proc Natl Acad Sci U S A. 1987 Dec.

Abstract

The tumor necrosis factor (TNF) alpha and beta gene pair has been linked in the human major histocompatibility complex to HLA-B, HLA-C, and, tentatively, HLA-E and HLA-A on one side and to the class III complement/steroid 21-hydroxylase gene cluster on the other by pulsed-field gel electrophoresis. The TNF genes are located 200 kilobases (kb) centromeric of HLA-B and about 350 kb telomeric of the class III cluster. Together with previous data on the linkage and structures of the class II and class III regions, a restriction map of the entire human major histocompatibility complex of about 3500 kb has been prepared.

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References

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