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. 2017 Mar 3;120(5):781-783.
doi: 10.1161/CIRCRESAHA.116.310007.

The Phospholamban Journey 4 Decades After Setting Out for Ithaka

Evangelia G Kranias  1 , Roger J Hajjar  2
Affiliations

The Phospholamban Journey 4 Decades After Setting Out for Ithaka

Evangelia G Kranias et al. Circ Res. .
No abstract available

Keywords: catecholamines; cell survival; heart failure; mutation; sarcoplasmic reticulum.

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References

    1. Tada M, Kirchberger MA, Katz AM. Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3′:5′-monophosphate-dependent protein kinase. J Biol Chem. 1975;250:2640–2647. - PubMed
    1. Simmerman HKB, Jones LR. Phospholamban: Protein Structure, Mechanism of Action, and Role in Cardiac Function. Physiol Rev. 1998;78:921–947. - PubMed
    1. Kranias EG, Solaro RJ. Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart. Nature. 1982;298:182–184. - PubMed
    1. Luo W, Grupp IL, Harrer J, Ponniah S, Grupp G, Duffy JJ, Doetschman T, Kranias EG. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res. 1994;75:401–409. - PubMed
    1. Kadambi VJ, Ponniah S, Harrer JM, Hoit BD, Dorn GW, Walsh RA, Kranias EG. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. J Clin Invest. 1996;97:533–539. - PMC - PubMed

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