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. 2017 Jul:186:57-63.e4.
doi: 10.1016/j.jpeds.2017.02.004. Epub 2017 Feb 28.

Early Infant Growth Velocity Patterns and Cardiovascular and Metabolic Outcomes in Childhood

Tamara Marinkovic  1 , Liza Toemen  1 , Claudia J Kruithof  2 , Irwin Reiss  3 , Lennie van Osch-Gevers  3 , Albert Hofman  4 , Oscar H Franco  5 , Vincent W V Jaddoe  6
Affiliations

Early Infant Growth Velocity Patterns and Cardiovascular and Metabolic Outcomes in Childhood

Tamara Marinkovic et al. J Pediatr. 2017 Jul.

Abstract

Objective: To evaluate the impact of infant growth on childhood health by examining the associations of detailed longitudinal infant weight velocity patterns with childhood cardiovascular and metabolic outcomes.

Study design: In a population-based prospective cohort study of 4649 children, we used repeated growth measurements at age 0-3 years to derive peak weight velocity (PWV), age at adiposity peak (AGEAP), and body mass index at adiposity peak (BMIAP). At age 6 years, we measured blood pressure, left ventricular mass, and cholesterol, triglyceride, and insulin concentrations and defined children with clusters of risk factors. We assessed associations using 2 multivariable linear regression models.

Results: A 1-SDS-higher infant PWV was associated with higher diastolic blood pressure (0.05 SDS; 95% CI, 0.02-0.09) and lower left ventricular mass (-0.05 SDS; 95% CI, -0.09 to -0.01), independent of body size. A 1-SDS-higher BMIAP was associated with higher systolic (0.12; 95% CI, 0.09-0.16) and diastolic (0.05; 95% CI, 0.01-0.08) blood pressure, but these associations were explained by childhood BMI. We did not observe any associations of PWV, BMIAP, and AGEAP with cholesterol and insulin concentrations. Higher PWV and AGEAP were associated with elevated risk of clustering of cardiovascular risk factors in childhood (P < .05).

Conclusion: Infant weight velocity patterns are associated with cardiovascular outcomes. Further studies are needed to explore the associations with metabolic outcomes and long-term consequences.

Keywords: cardiovascular risk factors; cohort; growth patterns; infancy.

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Conflict of interest statement

The authors declare no conflicts of interest.

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References

    1. Barker DJ, Osmond C, Forsen TJ, Kajantie E, Eriksson JG. Trajectories of growth among children who have coronary events as adults. N Engl J Med. 2005 Oct 27;353(17):1802–9. - PubMed
    1. Law CM, Shiell AW, Newsome CA, Syddall HE, Shinebourne EA, Fayers PM, et al. Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age. Circulation. 2002 Mar 5;105(9):1088–92. - PubMed
    1. Eriksson J, Forsen T, Tuomilehto J, Osmond C, Barker D. Fetal and childhood growth and hypertension in adult life. Hypertension. 2000 Nov;36(5):790–4. - PubMed
    1. Barker DJ, Martyn CN, Osmond C, Hales CN, Fall CH. Growth in utero and serum cholesterol concentrations in adult life. Bmj. 1993 Dec 11;307(6918):1524–7. - PMC - PubMed
    1. Leunissen RW, Kerkhof GF, Stijnen T, Hokken-Koelega A. Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood. Jama. 2009 Jun 3;301(21):2234–42. - PubMed

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