The role of initial clinical presentation, comorbidity and treatment in multiple myeloma patients on survival: a detailed population-based cohort study

Abstract

Purpose: This prospective, observational population-based cohort study was performed to determine overall survival (OS) in multiple myeloma (MM) patients in Friesland, the Netherlands, in the era of novel agents and to analyse the influence of first-line treatment, MM-related end-organ damage and comorbidities at initial presentation on OS.

Methods: Detailed clinical information was obtained from the population-based registry 'HemoBase' during the period January 2005 to January 2013, with a follow-up to January 2014.

Results: Overall, the symptomatic MM patients (n = 225) had a median OS of 40 months. In the age categories <65, 65-75 and ≥75 years, 99, 94 and 87% of the patients received treatment, with a median OS of 92, 42 and 31 months, respectively. OS for patients with or without treatment was 43 and 3 months, respectively. In multivariable analysis, risk factors for worse OS were increasing age (<65: reference; 65-75: HR_adj. = 2.2 (95% CI 1.3-3.7) and ≥75: HR_adj. = 2.8 (95% CI 1.7-4.8); P < 0.001), not receiving initial treatment (HR_adj. = 4.0 (95% CI 2.1-7.7); P < 0.001), hypercalcaemia (P < 0.001, HR_adj. = 1.7 (95% CI 1.2-2.6), P = 0.006) and impaired renal function (HR_adj. = 2.6 (95% CI 1.7-4.0); P < 0.001).

Conclusions: Increasing age, not receiving initial treatment, hypercalcaemia and impaired renal function at initial presentation were independent risk factors for worse OS. Comorbidity according to Charlson comorbidity index score was not an independent variable predicting OS.

Keywords: Clinical parameters; Multiple myeloma; Novel agents; Overall survival; Population-based registry.