Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul;28(7):709-716.
doi: 10.1007/s10552-017-0871-5. Epub 2017 Mar 4.

Older age at the completion of linear growth is associated with an increased risk of adult glioma

Rebecca B Little  1 , L Burt Nabors  2 , Jeffrey J Olson  3 , Zachary J Thompson  4 , Carrie M Rozmeski  4 , Renato V LaRocca  5 , Peter A Forsyth  6 , Reid C Thompson  7 , Robert A Oster  8 , Sajeel A Chowdhary  9 , Kathleen M Egan  10
Affiliations

Older age at the completion of linear growth is associated with an increased risk of adult glioma

Rebecca B Little et al. Cancer Causes Control. 2017 Jul.

Erratum in

Abstract

Purpose: To examine the association of age when adult height was attained with glioma risk.

Methods: We analyzed data from a US-based case-control study of glioma risk factors. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated between age at attainment of adult height and glioma risk. Multivariate models were adjusted for age, race, sex, education, and state of residence. We examined associations overall, and according to glioma grade, sex, and final adult height.

Results: The study set included n = 951 controls and n = 776 cases, with a median age of 56 (18-92); the majority was male (53.8%) and identified as Caucasian. Older age at height completion was associated with an increased risk of glioma. A significant positive trend was observed both for glioblastoma (OR 1.10; 95% CI 1.04-1.17 per 1-year increase in age) and lower grade non-glioblastoma subtypes combined (OR 1.18; 95% CI 1.10-1.28 per year increase in age). The association was observed in men and women, and in all categories of final adult height.

Conclusions: We observed for the first time a positive association between glioma risk and a prolonged adolescent growth phase. Our results suggest a role for factors governing the timing and intensity of growth in adolescence as risk-determining exposures in adult glioma.

Keywords: Adolescence; Case–control studies; Glioblastoma; Glioma; Height; Menarche.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest: The authors declare they have no conflicts of interest.

References

    1. Kohler BA, Ward E, McCarthy BJ, Schymura MJ, Ries LA, Eheman C, Jemal A, Anderson RN, Ajani UA, Edwards BK. Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system. Journal of the National Cancer Institute. 2011;103(9):714–736. doi: 10.1093/jnci/djr077. - DOI - PMC - PubMed
    1. Farrell CJ, Plotkin SR. Genetic causes of brain tumors: neurofibromatosis, tuberous sclerosis, von Hippel-Lindau, and other syndromes. Neurologic clinics. 2007;25(4):925–946. doi: 10.1016/j.ncl.2007.07.008. viii. - DOI - PubMed
    1. Rice T, Lachance DH, Molinaro AM, Eckel-Passow JE, Walsh KM, Barnholtz-Sloan J, Ostrom QT, Francis SS, Wiemels J, Jenkins RB, Wiencke JK, Wrensch MR. Understanding inherited genetic risk of adult glioma - a review. Neuro-oncology practice. 2016;3(1):10–16. doi: 10.1093/nop/npv026. - DOI - PMC - PubMed
    1. Braganza MZ, Kitahara CM, Berrington de Gonzalez A, Inskip PD, Johnson KJ, Rajaraman P. Ionizing radiation and the risk of brain and central nervous system tumors: a systematic review. Neuro-oncology. 2012;14(11):1316–1324. doi: 10.1093/neuonc/nos208. - DOI - PMC - PubMed
    1. Amirian ES, Scheurer ME, Zhou R, Wrensch MR, Armstrong GN, Lachance D, Olson SH, Lau CC, Claus EB, Barnholtz-Sloan JS, Il'yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, Jenkins RB, Bernstein JL, Merrell RT, Davis FG, Lai R, Shete S, Amos CI, Melin BS, Bondy ML. History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC) Cancer medicine. 2016;5(6):1352–1358. doi: 10.1002/cam4.682. - DOI - PMC - PubMed

LinkOut - more resources